Nan Lin

TL;DR: Patients' tendency to under-represent their functional decline was related to degeneration of domain-general dorsal frontal regions involved in attention, as well as orbitofrontal and subcortical regions likely involved in assigning a reward value to self-related processing and maintaining accurate self-knowledge.

TL;DR: In this article, the authors report ratings of occupational prestige by urban residents in Beijing, China using a representative sample (N = 1,632) of adults aged 20-64 and a selected group of 50 occupations.

TL;DR: Results in culture and in mice provide support for a readily implemented strategy by which the heterogeneity and evolvability of metastatic ER+ breast tumors, and perhaps other advanced cancers, might be controlled and provide promising proof of principle for a generalizable strategy to combat the pervasive problem of rapidly emerging resistance to molecularly targeted therapeutics.

TL;DR: Very small tumors with four positive LNs may predict for higher BCSM compared with larger tumors, and in extensive node-positive disease, very small tumor size may be a surrogate for biologically aggressive disease.

TL;DR: Findings suggest that a biomarker-driven clinical trial of PI3K inhibitor in combination with an mTOR inhibitor should be conducted for patients with HER2-positive BCBM.