N
Narghes Calcagno
Researcher at Brigham and Women's Hospital
Publications - 13
Citations - 1747
Narghes Calcagno is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Amyotrophic lateral sclerosis & Medicine. The author has an hindex of 6, co-authored 8 publications receiving 1115 citations. Previous affiliations of Narghes Calcagno include Massachusetts Eye and Ear Infirmary & University of Milan.
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Journal ArticleDOI
The TREM2-APOE Pathway Drives the Transcriptional Phenotype of Dysfunctional Microglia in Neurodegenerative Diseases
Susanne Krasemann,Susanne Krasemann,Charlotte Madore,Ron Cialic,Caroline Baufeld,Narghes Calcagno,Rachid El Fatimy,Lien Beckers,Elaine O’Loughlin,Yang Xu,Zain Fanek,David J. Greco,Scott T. Smith,George Tweet,Zachary Humulock,Tobias Zrzavy,Patricia Conde-Sanroman,Mar Gacias,Zhiping Weng,Hao Chen,Emily C. Tjon,Fargol Mazaheri,Kristin Hartmann,Asaf Madi,Jason D. Ulrich,Markus Glatzel,Anna Worthmann,Joerg Heeren,Bogdan Budnik,Cynthia A. Lemere,Tsuneya Ikezu,Frank L. Heppner,Vladimir Litvak,David M. Holtzman,Hans Lassmann,Howard L. Weiner,Jordi Ochando,Christian Haass,Oleg Butovsky +38 more
TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.
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Differential contribution of microglia and monocytes in neurodegenerative diseases
TL;DR: This review will summarize and discuss the current knowledge of the differential contributions of microglia and monocytes in the common neurodegenerative diseases AD, PD, and ALS, as well as multiple sclerosis, which is now regarded as a combination of inflammatory processes and Neurodegeneration.
Journal ArticleDOI
Synapse density and dendritic complexity are reduced in the prefrontal cortex following seven days of forced abstinence from cocaine self-administration.
Khampaseuth Rasakham,Heath D. Schmidt,Kevin R Kay,Megan N. Huizenga,Narghes Calcagno,R. Christopher Pierce,Tara L. Spires-Jones,Ghazaleh Sadri-Vakili +7 more
TL;DR: Findings indicate that dynamic structural changes occur during cocaine abstinence that may contribute to the observed hypo-activity of the PFC in cocaine-addicted individuals.
Journal ArticleDOI
Rising evidence for neurological involvement in COVID-19 pandemic.
Narghes Calcagno,Eleonora Colombo,Alessio Maranzano,Jacopo Pasquini,Ignacio Juan Keller Sarmiento,Francesca Trogu,Vincenzo Silani +6 more
TL;DR: Clinically, COVID-19 is primarily a respiratory disease marked by fever, cough, and shortness of breath, and in a small percentage of cases, it can lead to severe respiratory complications and death.
Journal ArticleDOI
Graft Site Microenvironment Determines Dendritic Cell Trafficking Through the CCR7-CCL19/21 Axis
Jing Hua,William Stevenson,Thomas H. Dohlman,Takenori Inomata,Maryam Tahvildari,Narghes Calcagno,Negar Pirmadjid,Zahra Sadrai,Sunil K. Chauhan,Reza Dana +9 more
TL;DR: It is found that inflamed graft sites greatly promote the trafficking of both recipient- and graft-derived APCs, in particular mature CCR7+ CD11c+ dendritic cells (DC).