Bogdan Budnik

TL;DR: The TREM2-APOE pathway is identified as a major regulator of microglial functional phenotype in neurodegenerative diseases and serves as a novel target that could aid in the restoration of homeostatic microglia.

TL;DR: A peptidomic strategy to detect short ORF (sORF)-encoded polypeptides (SEPs) in human cells is developed, and 90 SEPs are identified, 86 of which are novel, the largest number of human SEPs ever reported.

TL;DR: This work develops Single Cell ProtEomics by Mass Spectrometry (SCoPE-MS) and validate its ability to identify distinct human cancer cell types based on their proteomes and uses it to quantify over a thousand proteins in differentiating mouse embryonic stem cells.

TL;DR: It is proposed that most heat-induced aggregation of mature proteins reflects the operation of an adaptive, autoregulatory process of functionally significant aggregate assembly and disassembly that aids cellular adaptation to thermal stress.

TL;DR: Assuming that most misfolded proteins impose similar costs, yeast cells express almost all proteins at steady-state levels sufficient to expose their encoding genes to selection against misfolding, lending credibility to the recent suggestion that such selection imposes a global constraint on molecular evolution.