N
Natascha van Lieshout
Researcher at Wageningen University and Research Centre
Publications - 8
Citations - 1040
Natascha van Lieshout is an academic researcher from Wageningen University and Research Centre. The author has contributed to research in topics: Genome & Sequence assembly. The author has an hindex of 6, co-authored 8 publications receiving 521 citations. Previous affiliations of Natascha van Lieshout include University of Waterloo & University of Toronto.
Papers
More filters
Journal ArticleDOI
A reference map of the human binary protein interactome
Katja Luck,Dae-Kyum Kim,Luke Lambourne,Kerstin Spirohn,Bridget E. Begg,Wenting Bian,Ruth Brignall,Tiziana M. Cafarelli,Francisco J. Campos-Laborie,Benoit Charloteaux,Dong-Sic Choi,Atina G. Cote,Meaghan Daley,Steven Deimling,Alice Desbuleux,Amélie Dricot,Marinella Gebbia,Madeleine F. Hardy,Nishka Kishore,Jennifer J. Knapp,István Kovács,István Kovács,Irma Lemmens,Irma Lemmens,Miles W. Mee,Joseph C. Mellor,Carl Pollis,Carles Pons,Aaron Richardson,Sadie Schlabach,Bridget Teeking,Anupama Yadav,Mariana Babor,Dawit Balcha,Omer Basha,Christian Bowman-Colin,Suet-Feung Chin,Soon Gang Choi,Claudia Colabella,Georges Coppin,Cassandra D’Amata,David De Ridder,Steffi De Rouck,Steffi De Rouck,Miquel Duran-Frigola,Hanane Ennajdaoui,Florian Goebels,Liana Goehring,Anjali Gopal,Ghazal Haddad,Elodie Hatchi,Mohamed Helmy,Yves Jacob,Yves Jacob,Yoseph Kassa,Serena Landini,Roujia Li,Natascha van Lieshout,Andrew MacWilliams,Dylan Markey,Joseph N. Paulson,Joseph N. Paulson,Sudharshan Rangarajan,John Rasla,Ashyad Rayhan,Thomas Rolland,Adriana San-Miguel,Yun Shen,Dayag Sheykhkarimli,Gloria M. Sheynkman,Eyal Simonovsky,Murat Tasan,Alexander O. Tejeda,Vincent Tropepe,Jean-Claude Twizere,Yang Wang,Robert J. Weatheritt,Jochen Weile,Yu Xia,Yu Xia,Xinping Yang,Esti Yeger-Lotem,Quan Zhong,Patrick Aloy,Gary D. Bader,Javier De Las Rivas,Suzanne Gaudet,Tong Hao,Janusz Rak,Jan Tavernier,Jan Tavernier,David E. Hill,Marc Vidal,Frederick P. Roth,Michael A. Calderwood +94 more
TL;DR: The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.
Journal ArticleDOI
Exploring genetic suppression interactions on a global scale
Jolanda van Leeuwen,Carles Pons,Joseph C. Mellor,Joseph C. Mellor,Takafumi N. Yamaguchi,Takafumi N. Yamaguchi,Helena Friesen,John H. Koschwanez,Mojca Mattiazzi Usaj,Maria Pechlaner,Mehmet Takar,Matej Usaj,Benjamin VanderSluis,Kerry Andrusiak,Pritpal Bansal,Pritpal Bansal,Anastasia Baryshnikova,Claire E. Boone,Jessica Cao,Atina G. Cote,Atina G. Cote,Marinella Gebbia,Marinella Gebbia,Gene Horecka,Ira Horecka,Elena Kuzmin,Nicole Legro,Wendy Liang,Natascha van Lieshout,Natascha van Lieshout,Margaret McNee,Bryan-Joseph San Luis,Fatemeh Shaeri,Fatemeh Shaeri,Ermira Shuteriqi,Song Sun,Lu Yang,Ji-Young Youn,Michael Yuen,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Patrick Aloy,Chris Oostenbrink,Andrew W. Murray,Todd R. Graham,Chad L. Myers,Chad L. Myers,Brenda J. Andrews,Frederick P. Roth,Charles Boone,Charles Boone +51 more
TL;DR: A large-scale study in yeast reveals how defects associated with a mutation in one gene can be compensated for by a second mutation in a suppressor gene, and assembled a global network of genetic suppression interactions, which highlights the major potential for systematic studies of suppression to map cellular function.
Journal ArticleDOI
A framework for exhaustively mapping functional missense variants
Jochen Weile,Song Sun,Atina G. Cote,Atina G. Cote,Jennifer J. Knapp,Jennifer J. Knapp,Marta Verby,Marta Verby,Joseph C. Mellor,Yingzhou Wu,Carles Pons,Chi-Huey Wong,Chi-Huey Wong,Natascha van Lieshout,Fan Yang,Murat Tasan,Guihong Tan,Shan Yang,Douglas M. Fowler,Robert L. Nussbaum,Jesse D. Bloom,Marc Vidal,David E. Hill,Patrick Aloy,Frederick P. Roth +24 more
TL;DR: A deep mutational scanning framework is developed that produces exhaustive maps for human missense variants by combining random codon mutagenesis and multiplexed functional variation assays with computational imputation and refinement.
Posted ContentDOI
A reference map of the human protein interactome
Katja Luck,Dae-Kyum Kim,Dae-Kyum Kim,Luke Lambourne,Kerstin Spirohn,Bridget E. Begg,Wenting Bian,Ruth Brignall,Tiziana M. Cafarelli,Francisco J. Campos-Laborie,Benoit Charloteaux,Dong-Sic Choi,Atina G. Cote,Atina G. Cote,Meaghan Daley,Steven Deimling,Alice Desbuleux,Alice Desbuleux,Amélie Dricot,Marinella Gebbia,Marinella Gebbia,Madeleine F. Hardy,Nishka Kishore,Nishka Kishore,Jennifer J. Knapp,Jennifer J. Knapp,István Kovács,István Kovács,István Kovács,Irma Lemmens,Irma Lemmens,Miles W. Mee,Joseph C. Mellor,Joseph C. Mellor,Carl Pollis,Carles Pons,Aaron Richardson,Sadie Schlabach,Bridget Teeking,Anupama Yadav,Mariana Babor,Mariana Babor,Dawit Balcha,Omer Basha,Christian Bowman-Colin,Suet-Feung Chin,Soon Gang Choi,Claudia Colabella,Georges Coppin,Georges Coppin,Cassandra D’Amata,David De Ridder,Steffi De Rouck,Steffi De Rouck,Miquel Duran-Frigola,Hanane Ennajdaoui,Hanane Ennajdaoui,Florian Goebels,Liana Goehring,Anjali Gopal,Anjali Gopal,Ghazal Haddad,Ghazal Haddad,Elodie Hatchi,Mohamed Helmy,Yves Jacob,Yves Jacob,Yoseph Kassa,Serena Landini,Roujia Li,Roujia Li,Natascha van Lieshout,Natascha van Lieshout,Andrew MacWilliams,Dylan Markey,Joseph N. Paulson,Joseph N. Paulson,Sudharshan Rangarajan,John Rasla,Ashyad Rayhan,Ashyad Rayhan,Thomas Rolland,Adriana San-Miguel,Yun Shen,Dayag Sheykhkarimli,Dayag Sheykhkarimli,Gloria M. Sheynkman,Eyal Simonovsky,Murat Tasan,Murat Tasan,Alexander O. Tejeda,Jean-Claude Twizere,Yang Wang,Robert J. Weatheritt,Jochen Weile,Jochen Weile,Yu Xia,Yu Xia,Xinping Yang,Esti Yeger-Lotem,Quan Zhong,Quan Zhong,Patrick Aloy,Gary D. Bader,Javier De Las Rivas,Suzanne Gaudet,Tong Hao,Janusz Rak,Jan Tavernier,Jan Tavernier,Vincent Tropepe,David E. Hill,Marc Vidal,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,Michael A. Calderwood +116 more
TL;DR: The first human “all-by-all” binary reference interactome map, or HuRI, is presented and it is demonstrated the use of HuRI in identifying specific subcellular roles of PPIs and protein function modulation via splicing during brain development.
Journal ArticleDOI
Systematic analysis of bypass suppression of essential genes.
Jolanda van Leeuwen,Jolanda van Leeuwen,Carles Pons,Guihong Tan,Jason Z Ya Wang,Jing Hou,Jochen Weile,Jochen Weile,Marinella Gebbia,Marinella Gebbia,Wendy Liang,Ermira Shuteriqi,Zhijian Li,Maykel Lopes,Matej Usaj,Andreia Dos Santos Lopes,Natascha van Lieshout,Natascha van Lieshout,Chad L. Myers,Frederick P. Roth,Patrick Aloy,Brenda J. Andrews,Charles Boone +22 more
TL;DR: Yeast's core essential gene set is identified and the properties of dispensable essential genes are conserved from yeast to human cells, correlating with human genes that display cell line‐specific essentiality in the Cancer Dependency Map (DepMap) project.