C
Christian Bowman-Colin
Researcher at Harvard University
Publications - 16
Citations - 1812
Christian Bowman-Colin is an academic researcher from Harvard University. The author has contributed to research in topics: DNA damage & DNA repair. The author has an hindex of 12, co-authored 16 publications receiving 1174 citations. Previous affiliations of Christian Bowman-Colin include University of São Paulo.
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Journal ArticleDOI
A reference map of the human binary protein interactome
Katja Luck,Dae-Kyum Kim,Luke Lambourne,Kerstin Spirohn,Bridget E. Begg,Wenting Bian,Ruth Brignall,Tiziana M. Cafarelli,Francisco J. Campos-Laborie,Benoit Charloteaux,Dong-Sic Choi,Atina G. Cote,Meaghan Daley,Steven Deimling,Alice Desbuleux,Amélie Dricot,Marinella Gebbia,Madeleine F. Hardy,Nishka Kishore,Jennifer J. Knapp,István Kovács,István Kovács,Irma Lemmens,Irma Lemmens,Miles W. Mee,Joseph C. Mellor,Carl Pollis,Carles Pons,Aaron Richardson,Sadie Schlabach,Bridget Teeking,Anupama Yadav,Mariana Babor,Dawit Balcha,Omer Basha,Christian Bowman-Colin,Suet-Feung Chin,Soon Gang Choi,Claudia Colabella,Georges Coppin,Cassandra D’Amata,David De Ridder,Steffi De Rouck,Steffi De Rouck,Miquel Duran-Frigola,Hanane Ennajdaoui,Florian Goebels,Liana Goehring,Anjali Gopal,Ghazal Haddad,Elodie Hatchi,Mohamed Helmy,Yves Jacob,Yves Jacob,Yoseph Kassa,Serena Landini,Roujia Li,Natascha van Lieshout,Andrew MacWilliams,Dylan Markey,Joseph N. Paulson,Joseph N. Paulson,Sudharshan Rangarajan,John Rasla,Ashyad Rayhan,Thomas Rolland,Adriana San-Miguel,Yun Shen,Dayag Sheykhkarimli,Gloria M. Sheynkman,Eyal Simonovsky,Murat Tasan,Alexander O. Tejeda,Vincent Tropepe,Jean-Claude Twizere,Yang Wang,Robert J. Weatheritt,Jochen Weile,Yu Xia,Yu Xia,Xinping Yang,Esti Yeger-Lotem,Quan Zhong,Patrick Aloy,Gary D. Bader,Javier De Las Rivas,Suzanne Gaudet,Tong Hao,Janusz Rak,Jan Tavernier,Jan Tavernier,David E. Hill,Marc Vidal,Frederick P. Roth,Michael A. Calderwood +94 more
TL;DR: The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.
Journal ArticleDOI
Telomeric Allelic Imbalance Indicates Defective DNA Repair and Sensitivity to DNA-Damaging Agents
Nicolai Juul Birkbak,Nicolai Juul Birkbak,Zhigang C. Wang,Zhigang C. Wang,Ji Young Kim,Aron Charles Eklund,Qiyuan Li,Qiyuan Li,Ruiyang Tian,Christian Bowman-Colin,Yang Li,April Greene-Colozzi,J. Dirk Iglehart,J. Dirk Iglehart,Nadine Tung,Paula D. Ryan,Judy Garber,Daniel P. Silver,Daniel P. Silver,Zoltan Szallasi,Zoltan Szallasi,Andrea L. Richardson,Andrea L. Richardson +22 more
TL;DR: NtAI, a genomic measure of unfaithfully repaired DNA, may identify cancer patients likely to benefit from treatments targeting defective DNA repair, and suggests impaired DNA repair in patients treated with platinum-based chemotherapy.
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An in-tumor genetic screen reveals that the BET bromodomain protein, BRD4, is a potential therapeutic target in ovarian carcinoma
Maria Giuseppina Baratta,Anna C. Schinzel,Yaara Zwang,Pratiti Bandopadhayay,Christian Bowman-Colin,Jennifer Kutt,Jennifer E. Curtis,Huiying Piao,Laura C. Wong,Andrew L. Kung,Rameen Beroukhim,James E. Bradner,Ronny Drapkin,William C. Hahn,Joyce F. Liu,David M. Livingston +15 more
TL;DR: It is demonstrated that inhibition of the BET bromodomain protein, BRD4, is a potential therapeutic approach to high-grade epithelial ovarian cancers that exhibit elevated MYCN expression, and suggested that BRD 4 inhibition represents a new therapeutic approach for MYC-overexpressing HGSOCs.
Journal ArticleDOI
BRCA1 haploinsufficiency for replication stress suppression in primary cells
Shailja Pathania,Sangeeta Bade,Morwenna Le Guillou,Karly Burke,Rachel Reed,Christian Bowman-Colin,Ying Su,David T. Ting,Kornelia Polyak,Andrea L. Richardson,Jean Feunteun,Judy Garber,David M. Livingston +12 more
TL;DR: It is reported that all BRCA1mut/+ cells exhibited multiple normal BrcA1 functions, including the support of homologous recombination- type double-strand break repair (HR-DSBR), checkpoint functions, centrosome number control, spindle pole formation, Slug expression and satellite RNA suppression.
Journal ArticleDOI
Autophagy Opposes p53-Mediated Tumor Barrier to Facilitate Tumorigenesis in a Model of PALB2-Associated Hereditary Breast Cancer
Yanying Huo,Hong Cai,Irina Teplova,Christian Bowman-Colin,Guanghua Chen,Sandy M. Price,Nicola Barnard,Shridar Ganesan,Vassiliki Karantza,Eileen White,Bing Xia +10 more
TL;DR: It is shown that similar to Brca1 and Brca2, ablation of Palb2 in the mouse mammary gland resulted in tumor development with long latency, and the tumors harbored mutations in Trp53.