J
Jolanda van Leeuwen
Researcher at University of Toronto
Publications - 28
Citations - 2506
Jolanda van Leeuwen is an academic researcher from University of Toronto. The author has contributed to research in topics: Gene & Genome. The author has an hindex of 16, co-authored 24 publications receiving 1856 citations. Previous affiliations of Jolanda van Leeuwen include VU University Amsterdam & University of Lausanne.
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Journal ArticleDOI
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo,Benjamin VanderSluis,Elizabeth N. Koch,Anastasia Baryshnikova,Carles Pons,Guihong Tan,Wen Wang,Matej Usaj,Julia Hanchard,Susan D. Lee,Vicent Pelechano,Erin B. Styles,Maximilian Billmann,Jolanda van Leeuwen,Nydia Van Dyk,Zhen Yuan Lin,Elena Kuzmin,Justin Nelson,Jeff S. Piotrowski,Tharan Srikumar,Sondra Bahr,Yiqun Chen,Raamesh Deshpande,Christoph F. Kurat,Sheena C. Li,Zhijian Li,Mojca Mattiazzi Usaj,Hiroki Okada,Natasha Pascoe,Bryan Joseph San Luis,Sara Sharifpoor,Emira Shuteriqi,Scott W. Simpkins,Jamie Snider,Harsha Garadi Suresh,Yizhao Tan,Hongwei Zhu,Noël Malod-Dognin,Vuk Janjić,Natasa Przulj,Natasa Przulj,Olga G. Troyanskaya,Igor Stagljar,Tian Xia,Tian Xia,Yoshikazu Ohya,Anne-Claude Gingras,Brian Raught,Michael Boutros,Lars M. Steinmetz,Lars M. Steinmetz,Claire Moore,Adam P. Rosebrock,Amy A. Caudy,Chad L. Myers,Brenda J. Andrews,Charles Boone +56 more
TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Journal ArticleDOI
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.
Traver Hart,Amy Hin Yan Tong,Katie Chan,Jolanda van Leeuwen,Ashwin Seetharaman,Michael Aregger,Megha Chandrashekhar,Nicole Hustedt,Sahil Seth,Avery Noonan,Andrea Habsid,Olga Sizova,Lyudmila Nedyalkova,Ryan Climie,Leanne Tworzyanski,Keith A. Lawson,Maria A. Sartori,Sabriyeh Alibeh,David Tieu,Sanna Masud,Patricia Mero,Alexander Weiss,Kevin R. Brown,Matej Usaj,Maximilian Billmann,Mahfuzur Rahman,Michael Constanzo,Chad L. Myers,Brenda J. Andrews,Brenda J. Andrews,Charles Boone,Charles Boone,Daniel Durocher,Jason Moffat,Jason Moffat +34 more
TL;DR: The optimized TKOv3 library, combined with the CEG2 reference set, provide an efficient, highly optimized platform for performing and assessing gene knockout screens in human cell lines and are demonstrated to be high effectiveness relative to reference sets of essential and nonessential genes.
Journal ArticleDOI
Systematic analysis of complex genetic interactions
Elena Kuzmin,Benjamin VanderSluis,Wen Wang,Guihong Tan,Raamesh Deshpande,Yiqun Chen,Matej Usaj,Attila Balint,Mojca Mattiazzi Usaj,Jolanda van Leeuwen,Elizabeth N. Koch,Carles Pons,Andrius J. Dagilis,Michael Pryszlak,Jason Zi Yang Wang,Julia Hanchard,Margot Riggi,Kaicong Xu,Hamed Heydari,Bryan Joseph San Luis,Ermira Shuteriqi,Hongwei Zhu,Nydia Van Dyk,Sara Sharifpoor,Michael Costanzo,Robbie Loewith,Amy A. Caudy,Daniel I. Bolnick,Grant W. Brown,Brenda J. Andrews,Charles Boone,Chad L. Myers +31 more
TL;DR: The extensive network of trigenic interactions and their ability to generate functionally diverse phenotypes suggest that higher-order genetic interactions may play a key role in the genotype-to-phenotype relationship, genome size, and speciation.
Journal ArticleDOI
Global Genetic Networks and the Genotype-to-Phenotype Relationship
Michael Costanzo,Elena Kuzmin,Jolanda van Leeuwen,Barbara Mair,Jason Moffat,Charles Boone,Brenda J. Andrews +6 more
TL;DR: It is emphasized how information gained from work in yeast translates to other systems, and how a global genetic network not only annotates gene function but also provides new insights into the genotype-to-phenotype relationship.
Journal ArticleDOI
Exploring genetic suppression interactions on a global scale
Jolanda van Leeuwen,Carles Pons,Joseph C. Mellor,Joseph C. Mellor,Takafumi N. Yamaguchi,Takafumi N. Yamaguchi,Helena Friesen,John H. Koschwanez,Mojca Mattiazzi Usaj,Maria Pechlaner,Mehmet Takar,Matej Usaj,Benjamin VanderSluis,Kerry Andrusiak,Pritpal Bansal,Pritpal Bansal,Anastasia Baryshnikova,Claire E. Boone,Jessica Cao,Atina G. Cote,Atina G. Cote,Marinella Gebbia,Marinella Gebbia,Gene Horecka,Ira Horecka,Elena Kuzmin,Nicole Legro,Wendy Liang,Natascha van Lieshout,Natascha van Lieshout,Margaret McNee,Bryan-Joseph San Luis,Fatemeh Shaeri,Fatemeh Shaeri,Ermira Shuteriqi,Song Sun,Lu Yang,Ji-Young Youn,Michael Yuen,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Patrick Aloy,Chris Oostenbrink,Andrew W. Murray,Todd R. Graham,Chad L. Myers,Chad L. Myers,Brenda J. Andrews,Frederick P. Roth,Charles Boone,Charles Boone +51 more
TL;DR: A large-scale study in yeast reveals how defects associated with a mutation in one gene can be compensated for by a second mutation in a suppressor gene, and assembled a global network of genetic suppression interactions, which highlights the major potential for systematic studies of suppression to map cellular function.