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Nishka Kishore
Researcher at University of Toronto
Publications - 15
Citations - 1161
Nishka Kishore is an academic researcher from University of Toronto. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 5, co-authored 11 publications receiving 523 citations. Previous affiliations of Nishka Kishore include Harvard University & Lunenfeld-Tanenbaum Research Institute.
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Journal ArticleDOI
A reference map of the human binary protein interactome
Katja Luck,Dae-Kyum Kim,Luke Lambourne,Kerstin Spirohn,Bridget E. Begg,Wenting Bian,Ruth Brignall,Tiziana M. Cafarelli,Francisco J. Campos-Laborie,Benoit Charloteaux,Dong-Sic Choi,Atina G. Cote,Meaghan Daley,Steven Deimling,Alice Desbuleux,Amélie Dricot,Marinella Gebbia,Madeleine F. Hardy,Nishka Kishore,Jennifer J. Knapp,István Kovács,István Kovács,Irma Lemmens,Irma Lemmens,Miles W. Mee,Joseph C. Mellor,Carl Pollis,Carles Pons,Aaron Richardson,Sadie Schlabach,Bridget Teeking,Anupama Yadav,Mariana Babor,Dawit Balcha,Omer Basha,Christian Bowman-Colin,Suet-Feung Chin,Soon Gang Choi,Claudia Colabella,Georges Coppin,Cassandra D’Amata,David De Ridder,Steffi De Rouck,Steffi De Rouck,Miquel Duran-Frigola,Hanane Ennajdaoui,Florian Goebels,Liana Goehring,Anjali Gopal,Ghazal Haddad,Elodie Hatchi,Mohamed Helmy,Yves Jacob,Yves Jacob,Yoseph Kassa,Serena Landini,Roujia Li,Natascha van Lieshout,Andrew MacWilliams,Dylan Markey,Joseph N. Paulson,Joseph N. Paulson,Sudharshan Rangarajan,John Rasla,Ashyad Rayhan,Thomas Rolland,Adriana San-Miguel,Yun Shen,Dayag Sheykhkarimli,Gloria M. Sheynkman,Eyal Simonovsky,Murat Tasan,Alexander O. Tejeda,Vincent Tropepe,Jean-Claude Twizere,Yang Wang,Robert J. Weatheritt,Jochen Weile,Yu Xia,Yu Xia,Xinping Yang,Esti Yeger-Lotem,Quan Zhong,Patrick Aloy,Gary D. Bader,Javier De Las Rivas,Suzanne Gaudet,Tong Hao,Janusz Rak,Jan Tavernier,Jan Tavernier,David E. Hill,Marc Vidal,Frederick P. Roth,Michael A. Calderwood +94 more
TL;DR: The utility of HuRI is demonstrated in identifying the specific subcellular roles of protein–protein interactions and in identifying potential molecular mechanisms that might underlie tissue-specific phenotypes of Mendelian diseases.
Journal ArticleDOI
Network-based prediction of protein interactions.
István Kovács,Katja Luck,Kerstin Spirohn,Yang Wang,Carl Pollis,Sadie Schlabach,Wenting Bian,Dae-Kyum Kim,Dae-Kyum Kim,Nishka Kishore,Nishka Kishore,Tong Hao,Michael A. Calderwood,Marc Vidal,Albert-László Barabási +14 more
TL;DR: It is shown that proteins tend to interact if one is similar to the other’s partners and that PPI prediction based on this principle is highly accurate and can offer mechanistic insights into disease mechanisms and complement future experimental efforts to complete the human interactome.
Posted ContentDOI
Network-based prediction of protein interactions
István Kovács,Katja Luck,Kerstin Spirohn,Yang Wang,Carl Pollis,Sadie Schlabach,Wenting Bian,Dae-Kyum Kim,Nishka Kishore,Tong Hao,Michael A. Calderwood,Marc Vidal,Albert-László Barabási +12 more
TL;DR: A fundamental organizing principle of biological networks is unveiled, L3, that predicts yet uncovered protein interactions based on paths of length three (L3) and is expected to have a broad applicability, enabling to better understand the emergence of biological function under both healthy and pathological conditions.
Posted ContentDOI
A reference map of the human protein interactome
Katja Luck,Dae-Kyum Kim,Dae-Kyum Kim,Luke Lambourne,Kerstin Spirohn,Bridget E. Begg,Wenting Bian,Ruth Brignall,Tiziana M. Cafarelli,Francisco J. Campos-Laborie,Benoit Charloteaux,Dong-Sic Choi,Atina G. Cote,Atina G. Cote,Meaghan Daley,Steven Deimling,Alice Desbuleux,Alice Desbuleux,Amélie Dricot,Marinella Gebbia,Marinella Gebbia,Madeleine F. Hardy,Nishka Kishore,Nishka Kishore,Jennifer J. Knapp,Jennifer J. Knapp,István Kovács,István Kovács,István Kovács,Irma Lemmens,Irma Lemmens,Miles W. Mee,Joseph C. Mellor,Joseph C. Mellor,Carl Pollis,Carles Pons,Aaron Richardson,Sadie Schlabach,Bridget Teeking,Anupama Yadav,Mariana Babor,Mariana Babor,Dawit Balcha,Omer Basha,Christian Bowman-Colin,Suet-Feung Chin,Soon Gang Choi,Claudia Colabella,Georges Coppin,Georges Coppin,Cassandra D’Amata,David De Ridder,Steffi De Rouck,Steffi De Rouck,Miquel Duran-Frigola,Hanane Ennajdaoui,Hanane Ennajdaoui,Florian Goebels,Liana Goehring,Anjali Gopal,Anjali Gopal,Ghazal Haddad,Ghazal Haddad,Elodie Hatchi,Mohamed Helmy,Yves Jacob,Yves Jacob,Yoseph Kassa,Serena Landini,Roujia Li,Roujia Li,Natascha van Lieshout,Natascha van Lieshout,Andrew MacWilliams,Dylan Markey,Joseph N. Paulson,Joseph N. Paulson,Sudharshan Rangarajan,John Rasla,Ashyad Rayhan,Ashyad Rayhan,Thomas Rolland,Adriana San-Miguel,Yun Shen,Dayag Sheykhkarimli,Dayag Sheykhkarimli,Gloria M. Sheynkman,Eyal Simonovsky,Murat Tasan,Murat Tasan,Alexander O. Tejeda,Jean-Claude Twizere,Yang Wang,Robert J. Weatheritt,Jochen Weile,Jochen Weile,Yu Xia,Yu Xia,Xinping Yang,Esti Yeger-Lotem,Quan Zhong,Quan Zhong,Patrick Aloy,Gary D. Bader,Javier De Las Rivas,Suzanne Gaudet,Tong Hao,Janusz Rak,Jan Tavernier,Jan Tavernier,Vincent Tropepe,David E. Hill,Marc Vidal,Frederick P. Roth,Frederick P. Roth,Frederick P. Roth,Michael A. Calderwood +116 more
TL;DR: The first human “all-by-all” binary reference interactome map, or HuRI, is presented and it is demonstrated the use of HuRI in identifying specific subcellular roles of PPIs and protein function modulation via splicing during brain development.
Journal ArticleDOI
Shifting landscapes of human MTHFR missense-variant effects.
Jochen Weile,Nishka Kishore,Nishka Kishore,Song Sun,Ranim Maaieh,Marta Verby,Marta Verby,Roujia Li,Iosifina Fotiadou,Iosifina Fotiadou,Julia Kitaygorodsky,Julia Kitaygorodsky,Yingzhou Wu,Alexander Holenstein,Céline Bürer,Linnea Blomgren,Shan Yang,Robert L. Nussbaum,Rima Rozen,David Watkins,Marinella Gebbia,Marinella Gebbia,Viktor Kozich,Michael Garton,D. Sean Froese,Frederick P. Roth +25 more
TL;DR: In this paper, the authors describe the results of 98,336 variant functional-impact assays, covering nearly all possible MTHFR amino acid substitutions in four folinate environments, each in the presence and absence of p.Ala222Val.