M
Mojca Mattiazzi Usaj
Researcher at University of Toronto
Publications - 14
Citations - 1901
Mojca Mattiazzi Usaj is an academic researcher from University of Toronto. The author has contributed to research in topics: High-content screening & Gene regulatory network. The author has an hindex of 8, co-authored 14 publications receiving 1449 citations. Previous affiliations of Mojca Mattiazzi Usaj include Ryerson University.
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Journal ArticleDOI
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo,Benjamin VanderSluis,Elizabeth N. Koch,Anastasia Baryshnikova,Carles Pons,Guihong Tan,Wen Wang,Matej Usaj,Julia Hanchard,Susan D. Lee,Vicent Pelechano,Erin B. Styles,Maximilian Billmann,Jolanda van Leeuwen,Nydia Van Dyk,Zhen Yuan Lin,Elena Kuzmin,Justin Nelson,Jeff S. Piotrowski,Tharan Srikumar,Sondra Bahr,Yiqun Chen,Raamesh Deshpande,Christoph F. Kurat,Sheena C. Li,Zhijian Li,Mojca Mattiazzi Usaj,Hiroki Okada,Natasha Pascoe,Bryan Joseph San Luis,Sara Sharifpoor,Emira Shuteriqi,Scott W. Simpkins,Jamie Snider,Harsha Garadi Suresh,Yizhao Tan,Hongwei Zhu,Noël Malod-Dognin,Vuk Janjić,Natasa Przulj,Natasa Przulj,Olga G. Troyanskaya,Igor Stagljar,Tian Xia,Tian Xia,Yoshikazu Ohya,Anne-Claude Gingras,Brian Raught,Michael Boutros,Lars M. Steinmetz,Lars M. Steinmetz,Claire Moore,Adam P. Rosebrock,Amy A. Caudy,Chad L. Myers,Brenda J. Andrews,Charles Boone +56 more
TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Journal ArticleDOI
High-Content Screening for Quantitative Cell Biology.
Mojca Mattiazzi Usaj,Erin B. Styles,Adrian J. Verster,Helena Friesen,Charles Boone,Brenda J. Andrews +5 more
TL;DR: Some recent applications of HCS are described, ranging from the identification of genes required for specific biological processes to the characterization of genetic interactions, and major challenges associated with each are described.
Journal ArticleDOI
Systematic analysis of complex genetic interactions
Elena Kuzmin,Benjamin VanderSluis,Wen Wang,Guihong Tan,Raamesh Deshpande,Yiqun Chen,Matej Usaj,Attila Balint,Mojca Mattiazzi Usaj,Jolanda van Leeuwen,Elizabeth N. Koch,Carles Pons,Andrius J. Dagilis,Michael Pryszlak,Jason Zi Yang Wang,Julia Hanchard,Margot Riggi,Kaicong Xu,Hamed Heydari,Bryan Joseph San Luis,Ermira Shuteriqi,Hongwei Zhu,Nydia Van Dyk,Sara Sharifpoor,Michael Costanzo,Robbie Loewith,Amy A. Caudy,Daniel I. Bolnick,Grant W. Brown,Brenda J. Andrews,Charles Boone,Chad L. Myers +31 more
TL;DR: The extensive network of trigenic interactions and their ability to generate functionally diverse phenotypes suggest that higher-order genetic interactions may play a key role in the genotype-to-phenotype relationship, genome size, and speciation.
Journal ArticleDOI
Exploring genetic suppression interactions on a global scale
Jolanda van Leeuwen,Carles Pons,Joseph C. Mellor,Joseph C. Mellor,Takafumi N. Yamaguchi,Takafumi N. Yamaguchi,Helena Friesen,John H. Koschwanez,Mojca Mattiazzi Usaj,Maria Pechlaner,Mehmet Takar,Matej Usaj,Benjamin VanderSluis,Kerry Andrusiak,Pritpal Bansal,Pritpal Bansal,Anastasia Baryshnikova,Claire E. Boone,Jessica Cao,Atina G. Cote,Atina G. Cote,Marinella Gebbia,Marinella Gebbia,Gene Horecka,Ira Horecka,Elena Kuzmin,Nicole Legro,Wendy Liang,Natascha van Lieshout,Natascha van Lieshout,Margaret McNee,Bryan-Joseph San Luis,Fatemeh Shaeri,Fatemeh Shaeri,Ermira Shuteriqi,Song Sun,Lu Yang,Ji-Young Youn,Michael Yuen,Michael Costanzo,Anne-Claude Gingras,Anne-Claude Gingras,Patrick Aloy,Chris Oostenbrink,Andrew W. Murray,Todd R. Graham,Chad L. Myers,Chad L. Myers,Brenda J. Andrews,Frederick P. Roth,Charles Boone,Charles Boone +51 more
TL;DR: A large-scale study in yeast reveals how defects associated with a mutation in one gene can be compensated for by a second mutation in a suppressor gene, and assembled a global network of genetic suppression interactions, which highlights the major potential for systematic studies of suppression to map cellular function.
Journal ArticleDOI
The mammalian-membrane two-hybrid assay (MaMTH) for probing membrane-protein interactions in human cells
Julia Petschnigg,Bella Groisman,Max Kotlyar,Mikko Taipale,Yong Zheng,Christoph F. Kurat,Christoph F. Kurat,Azin Sayad,J Rafael Sierra,Mojca Mattiazzi Usaj,Jamie Snider,Alex Nachman,Irina Krykbaeva,Ming-Sound Tsao,Ming-Sound Tsao,Jason Moffat,Tony Pawson,Susan Lindquist,Susan Lindquist,Igor Jurisica,Igor Jurisica,Igor Stagljar +21 more
TL;DR: MaMTH can detect changes in PPIs conferred by mutations such as those in oncogenic ErbB receptor variants or by treatment with drugs such as the tyrosine kinase inhibitor erlotinib and is a powerful tool for investigating the dynamic interactomes of human integral membrane proteins.