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Natasha Pascoe
Researcher at University of Toronto
Publications - 3
Citations - 1061
Natasha Pascoe is an academic researcher from University of Toronto. The author has contributed to research in topics: Deubiquitinating enzyme & Gene. The author has an hindex of 2, co-authored 3 publications receiving 823 citations.
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Journal ArticleDOI
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo,Benjamin VanderSluis,Elizabeth N. Koch,Anastasia Baryshnikova,Carles Pons,Guihong Tan,Wen Wang,Matej Usaj,Julia Hanchard,Susan D. Lee,Vicent Pelechano,Erin B. Styles,Maximilian Billmann,Jolanda van Leeuwen,Nydia Van Dyk,Zhen Yuan Lin,Elena Kuzmin,Justin Nelson,Jeff S. Piotrowski,Tharan Srikumar,Sondra Bahr,Yiqun Chen,Raamesh Deshpande,Christoph F. Kurat,Sheena C. Li,Zhijian Li,Mojca Mattiazzi Usaj,Hiroki Okada,Natasha Pascoe,Bryan Joseph San Luis,Sara Sharifpoor,Emira Shuteriqi,Scott W. Simpkins,Jamie Snider,Harsha Garadi Suresh,Yizhao Tan,Hongwei Zhu,Noël Malod-Dognin,Vuk Janjić,Natasa Przulj,Natasa Przulj,Olga G. Troyanskaya,Igor Stagljar,Tian Xia,Tian Xia,Yoshikazu Ohya,Anne-Claude Gingras,Brian Raught,Michael Boutros,Lars M. Steinmetz,Lars M. Steinmetz,Claire Moore,Adam P. Rosebrock,Amy A. Caudy,Chad L. Myers,Brenda J. Andrews,Charles Boone +56 more
TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Journal ArticleDOI
The structure and function of deubiquitinases: lessons from budding yeast.
TL;DR: This review discusses the many layers of DUB function and regulation, with a focus on insights gained from budding yeast, and provides a framework to understand key aspects of Dub biology.
Journal ArticleDOI
Yeast Two-Hybrid Analysis for Ubiquitin Variant Inhibitors of Human Deubiquitinases.
Natasha Pascoe,Ashwin Seetharaman,Joan Teyra,Noah Manczyk,Maria Augusta Satori,Donna Tjandra,Taras Makhnevych,Carsten Schwerdtfeger,Bradley B. Brasher,Jason Moffat,Michael Costanzo,Charles Boone,Frank Sicheri,Sachdev S. Sidhu +13 more
TL;DR: Y2H is established as an effective platform for the development of UbV inhibitors of DUBs in vivo, providing an alternative strategy for the analysis of Dubs that are recalcitrant to phage display and other in vitro methods.