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Scott W. Simpkins
Researcher at University of Minnesota
Publications - 26
Citations - 1717
Scott W. Simpkins is an academic researcher from University of Minnesota. The author has contributed to research in topics: Population & Computer science. The author has an hindex of 12, co-authored 26 publications receiving 1256 citations. Previous affiliations of Scott W. Simpkins include Stanford University & Gustavus Adolphus College.
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Journal ArticleDOI
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo,Benjamin VanderSluis,Elizabeth N. Koch,Anastasia Baryshnikova,Carles Pons,Guihong Tan,Wen Wang,Matej Usaj,Julia Hanchard,Susan D. Lee,Vicent Pelechano,Erin B. Styles,Maximilian Billmann,Jolanda van Leeuwen,Nydia Van Dyk,Zhen Yuan Lin,Elena Kuzmin,Justin Nelson,Jeff S. Piotrowski,Tharan Srikumar,Sondra Bahr,Yiqun Chen,Raamesh Deshpande,Christoph F. Kurat,Sheena C. Li,Zhijian Li,Mojca Mattiazzi Usaj,Hiroki Okada,Natasha Pascoe,Bryan Joseph San Luis,Sara Sharifpoor,Emira Shuteriqi,Scott W. Simpkins,Jamie Snider,Harsha Garadi Suresh,Yizhao Tan,Hongwei Zhu,Noël Malod-Dognin,Vuk Janjić,Natasa Przulj,Natasa Przulj,Olga G. Troyanskaya,Igor Stagljar,Tian Xia,Tian Xia,Yoshikazu Ohya,Anne-Claude Gingras,Brian Raught,Michael Boutros,Lars M. Steinmetz,Lars M. Steinmetz,Claire Moore,Adam P. Rosebrock,Amy A. Caudy,Chad L. Myers,Brenda J. Andrews,Charles Boone +56 more
TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Journal ArticleDOI
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Kyuho Han,Sarah E. Pierce,Amy Li,Kaitlyn Spees,Grace R. Anderson,Jose A. Seoane,Yuan-Hung Lo,Michael M. Dubreuil,Micah Olivas,Roarke A. Kamber,Michael Wainberg,Kaja Kostyrko,Marcus R. Kelly,Maryam Yousefi,Scott W. Simpkins,David Yao,Keonil Lee,Calvin J. Kuo,Peter K. Jackson,Alejandro Sweet-Cordero,Anshul Kundaje,Andrew J. Gentles,Christina Curtis,Monte M. Winslow,Michael C. Bassik +24 more
TL;DR: A scalable cancer-spheroid model is devised and genome-wide CRISPR screens in 2D monolayers and 3D lung-cancer spheroids are performed to identify carboxypeptidase D, acting via the IGF1R, as a 3D-specific driver of cancer growth.
Journal ArticleDOI
Coculture of Marine Invertebrate-Associated Bacteria and Interdisciplinary Technologies Enable Biosynthesis and Discovery of a New Antibiotic, Keyicin.
Navid Adnani,Marc G. Chevrette,Srikar N. Adibhatla,Fan Zhang,Qing Yu,Doug R. Braun,Justin Nelson,Scott W. Simpkins,Bradon R. McDonald,Chad L. Myers,Jeff S. Piotrowski,Christopher J. Thompson,Cameron R. Currie,Lingjun Li,Scott R. Rajski,Tim S. Bugni +15 more
TL;DR: It is reported here that coculturing of a Rhodococcus sp.
Journal ArticleDOI
Functional annotation of chemical libraries across diverse biological processes
Jeff S. Piotrowski,Sheena C. Li,Raamesh Deshpande,Scott W. Simpkins,Justin Nelson,Yoko Yashiroda,Jacqueline M. Barber,Hamid Safizadeh,Erin H. Wilson,Hiroki Okada,Abraham A Gebre,Karen Kubo,Nikko P. Torres,Marissa A. LeBlanc,Kerry Andrusiak,Reika Okamoto,Mami Yoshimura,Eva DeRango-Adem,Jolanda van Leeuwen,Katsuhiko Shirahige,Anastasia Baryshnikova,Grant W. Brown,Hiroyuki Hirano,Michael Costanzo,Brenda J. Andrews,Yoshikazu Ohya,Hiroyuki Osada,Minoru Yoshida,Chad L. Myers,Charles Boone +29 more
TL;DR: This work constructed an optimized, diagnostic mutant collection that is predictive for all major yeast biological processes, and identified compounds that appear to have dual modes of action.
Posted ContentDOI
Swab-Seq: A high-throughput platform for massively scaled up SARS-CoV-2 testing
Joshua S. Bloom,Joshua S. Bloom,Laila Sathe,Chetan Munugala,Chetan Munugala,Eric T. Jones,Molly Gasperini,Nathan B. Lubock,Fauna Yarza,Erin M. Thompson,Kyle M. Kovary,Jimin Park,Dawn Marquette,Stephania Kay,Mark Lucas,TreQuan Love,A. Sina Booeshaghi,Oliver F. Brandenberg,Oliver F. Brandenberg,Longhua Guo,Longhua Guo,James Boocock,James Boocock,Myles Hochman,Scott W. Simpkins,Isabella Lin,Nathan LaPierre,Duke Hong,Yi Zhang,Gabriel Oland,Bianca Judy Choe,Sukantha Chandrasekaran,Evann E. Hilt,Manish J. Butte,Robert Damoiseaux,Robert Damoiseaux,Clifford Kravit,Aaron R. Cooper,Yi Yin,Lior Pachter,Omai B. Garner,Jonathan Flint,Eleazar Eskin,Chongyuan Luo,Sriram Kosuri,Leonid Kruglyak,Leonid Kruglyak,Valerie A. Arboleda +47 more
TL;DR: It is shown that SwabSeq can test nasal and oral specimens for SARS-CoV-2 with or without RNA extraction while maintaining analytical sensitivity better than or comparable to that of fluorescence-based RT-qPCR tests.