Erin B. Styles

TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.

TL;DR: Some recent applications of HCS are described, ranging from the identification of genes required for specific biological processes to the characterization of genetic interactions, and major challenges associated with each are described.

TL;DR: It is demonstrated that genetic screens in yeast can be used to determine candidate target genes for specific killing of cancer cells overexpressing dCin genes, and a list of dCIN candidate genes that can facilitate selective targeting of tumor cells is generated.

TL;DR: This work in yeast shows that proteasomes exit the nucleus with the transition from proliferation to quiescence and Ubiquitin is a key player in proteasome dynamics and cytoplasmic proteasomal granule formation.

TL;DR: An integrated method is presented that combines genome-wide genetic perturbation of Saccharomyces cerevisiae with high-content screening to facilitate the genetic description of sub-cellular structures and compartment morphology and is extensible to numerous other cell biological markers and experimental systems.