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Maximilian Billmann
Researcher at University of Minnesota
Publications - 23
Citations - 1896
Maximilian Billmann is an academic researcher from University of Minnesota. The author has contributed to research in topics: CRISPR & Gene. The author has an hindex of 9, co-authored 16 publications receiving 1420 citations. Previous affiliations of Maximilian Billmann include German Cancer Research Center & Heidelberg University.
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Journal ArticleDOI
A global genetic interaction network maps a wiring diagram of cellular function
Michael Costanzo,Benjamin VanderSluis,Elizabeth N. Koch,Anastasia Baryshnikova,Carles Pons,Guihong Tan,Wen Wang,Matej Usaj,Julia Hanchard,Susan D. Lee,Vicent Pelechano,Erin B. Styles,Maximilian Billmann,Jolanda van Leeuwen,Nydia Van Dyk,Zhen Yuan Lin,Elena Kuzmin,Justin Nelson,Jeff S. Piotrowski,Tharan Srikumar,Sondra Bahr,Yiqun Chen,Raamesh Deshpande,Christoph F. Kurat,Sheena C. Li,Zhijian Li,Mojca Mattiazzi Usaj,Hiroki Okada,Natasha Pascoe,Bryan Joseph San Luis,Sara Sharifpoor,Emira Shuteriqi,Scott W. Simpkins,Jamie Snider,Harsha Garadi Suresh,Yizhao Tan,Hongwei Zhu,Noël Malod-Dognin,Vuk Janjić,Natasa Przulj,Natasa Przulj,Olga G. Troyanskaya,Igor Stagljar,Tian Xia,Tian Xia,Yoshikazu Ohya,Anne-Claude Gingras,Brian Raught,Michael Boutros,Lars M. Steinmetz,Lars M. Steinmetz,Claire Moore,Adam P. Rosebrock,Amy A. Caudy,Chad L. Myers,Brenda J. Andrews,Charles Boone +56 more
TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.
Journal ArticleDOI
Evaluation and Design of Genome-Wide CRISPR/SpCas9 Knockout Screens.
Traver Hart,Amy Hin Yan Tong,Katie Chan,Jolanda van Leeuwen,Ashwin Seetharaman,Michael Aregger,Megha Chandrashekhar,Nicole Hustedt,Sahil Seth,Avery Noonan,Andrea Habsid,Olga Sizova,Lyudmila Nedyalkova,Ryan Climie,Leanne Tworzyanski,Keith A. Lawson,Maria A. Sartori,Sabriyeh Alibeh,David Tieu,Sanna Masud,Patricia Mero,Alexander Weiss,Kevin R. Brown,Matej Usaj,Maximilian Billmann,Mahfuzur Rahman,Michael Constanzo,Chad L. Myers,Brenda J. Andrews,Brenda J. Andrews,Charles Boone,Charles Boone,Daniel Durocher,Jason Moffat,Jason Moffat +34 more
TL;DR: The optimized TKOv3 library, combined with the CEG2 reference set, provide an efficient, highly optimized platform for performing and assessing gene knockout screens in human cell lines and are demonstrated to be high effectiveness relative to reference sets of essential and nonessential genes.
Journal ArticleDOI
Mapping genetic interactions in human cancer cells with RNAi and multiparametric phenotyping.
Christina Laufer,Bernd Fischer,Maximilian Billmann,Maximilian Billmann,Wolfgang Huber,Michael Boutros,Michael Boutros +6 more
TL;DR: This study described a robust and scalable method to systematically map genetic interactions in human cancer cells using combinatorial RNAi and high-throughput imaging, and measured genetic interactions across a broad spectrum of phenotypes, including cell count, cell eccentricity and nuclear area.
Journal ArticleDOI
A map of directional genetic interactions in a metazoan cell
Bernd Fischer,Thomas Sandmann,Thomas Sandmann,Thomas Horn,Thomas Horn,Maximilian Billmann,Maximilian Billmann,Varun Chaudhary,Varun Chaudhary,Wolfgang Huber,Michael Boutros,Michael Boutros +11 more
TL;DR: A method that combines genetic interactions on multiple phenotypes to reveal directional relationships is devised, which reconstructed the sequence of protein activities in mitosis and revealed that the Ras pathway interacts with the SWI/SNF chromatin-remodelling complex, an interaction that is conserved in human cancer cells.
Journal ArticleDOI
Genetic interaction mapping and exon-resolution functional genomics with a hybrid Cas9–Cas12a platform
Thomas Gonatopoulos-Pournatzis,Michael Aregger,Kevin R. Brown,Shaghayegh Farhangmehr,Ulrich Braunschweig,Henry N. Ward,Kevin C.H. Ha,Alexander Weiss,Maximilian Billmann,Tanja Durbic,Chad L. Myers,Benjamin J. Blencowe,Jason Moffat +12 more
TL;DR: CHyMErA represents an effective screening approach for GI mapping and the functional analysis of sizable genomic regions, such as alternative exons, when combining Cas9 and Cas12a outperforms previous approaches for combinatorial screening in mammalian cells.