Sheena C. Li

TL;DR: A global genetic interaction network highlights the functional organization of a cell and provides a resource for predicting gene and pathway function and how coherent sets of negative or positive genetic interactions connect protein complex and pathways to map a functional wiring diagram of the cell.

TL;DR: This review provides a broad overview of the defining features and functions of S. cerevisiae vacuoles and compares these features to mammalian lysosomes.

TL;DR: Purified Vo complexes bind preferentially to this lipid, and the cytosolic domain of one Vo subunit shows PI(3,5)P2-dependent recruitment to membranes in vivo.

TL;DR: The discovery of poacic acid as a natural antifungal agent targeting β-1,3-glucan highlights the potential side use of products generated in the processing of renewable biomass toward biofuels as a source of valuable bioactive compounds and further clarifies the nature and mechanism of fermentation inhibitors found in lignocellulosic hydrolysates.

TL;DR: This work constructed an optimized, diagnostic mutant collection that is predictive for all major yeast biological processes, and identified compounds that appear to have dual modes of action.