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Neeraj Pandey

Researcher at Washington University in St. Louis

Publications -  23
Citations -  1053

Neeraj Pandey is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Computer science & Metaverse. The author has an hindex of 8, co-authored 12 publications receiving 598 citations. Previous affiliations of Neeraj Pandey include University of Delhi & Council of Scientific and Industrial Research.

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Aggregation of alpha-synuclein by DOPAL, the monoamine oxidase metabolite of dopamine.

TL;DR: DOPAL in physiologically relevant concentrations, triggers AS aggregation in the cell-free system, and in cell cultures resulting in the formation of potentially toxic AS oligomers and aggregates, which support the hypothesis that DA metabolism via DOPAL can cause both DA neuron loss and AS aggregation observed in PD.
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Curcumin inhibits aggregation of α-synuclein

TL;DR: The data suggest that curcumin inhibits AS oligomerization into higher molecular weight aggregates and therefore should be further explored as a potential therapeutic compound for PD and related disorders.
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The alpha-synuclein mutation E46K promotes aggregation in cultured cells

TL;DR: The results demonstrate that mutations in 4th KTKEGV repeat lead to higher propensity of aggregation of AS compared to other mutants, and are reminiscent of Lewy bodies and pale bodies observed in PD postmortem brain samples.