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Ignasi Moran
Researcher at Imperial College London
Publications - 21
Citations - 2030
Ignasi Moran is an academic researcher from Imperial College London. The author has contributed to research in topics: Gene & Genome-wide association study. The author has an hindex of 11, co-authored 19 publications receiving 1666 citations. Previous affiliations of Ignasi Moran include Barcelona Supercomputing Center & Beta.
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Journal ArticleDOI
Pancreatic islet enhancer clusters enriched in type 2 diabetes risk-associated variants
Lorenzo Pasquali,Kyle J. Gaulton,Kyle J. Gaulton,Kyle J. Gaulton,Santiago A. Rodríguez-Seguí,Loris Mularoni,Irene Miguel-Escalada,Ildem Akerman,Juan J. Tena,Ignasi Moran,Carlos Gómez-Marín,Martijn van de Bunt,Martijn van de Bunt,Martijn van de Bunt,Joan Ponsa-Cobas,Natalia Castro,Takao Nammo,Inês Cebola,Javier García-Hurtado,Miguel Angel Maestro,François Pattou,Lorenzo Piemonti,Thierry Berney,Anna L. Gloyn,Anna L. Gloyn,Philippe Ravassard,José Luis Gómez Skarmeta,Ferenc Müller,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy,Jorge Ferrer +31 more
TL;DR: This work mapped and examined the function of human islet cis-regulatory networks and identifies genomic sequences that are targeted by islet transcription factors to drive islet-specific gene activity and shows that most such sequences reside in clusters of enhancers that form physical three-dimensional chromatin domains.
Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.
Journal ArticleDOI
The miRNA Profile of Human Pancreatic Islets and Beta-Cells and Relationship to Type 2 Diabetes Pathogenesis
Martijn van de Bunt,Martijn van de Bunt,Kyle J. Gaulton,Leopold Parts,Ignasi Moran,Paul Johnson,Paul Johnson,Cecilia M. Lindgren,Jorge Ferrer,Anna L. Gloyn,Anna L. Gloyn,Mark I. McCarthy,Mark I. McCarthy,Mark I. McCarthy +13 more
TL;DR: The miRNA profile of human islets and beta-cells is described and evidence linking islet miRNAs to T2D pathogenesis is provided.
Journal ArticleDOI
TEAD and YAP regulate the enhancer network of human embryonic pancreatic progenitors
Inês Cebola,Santiago A. Rodríguez-Seguí,Candy H.-H. Cho,José Bessa,José Bessa,Meritxell Rovira,Mario Luengo,Mariya Chhatriwala,Andrew Berry,Joan Ponsa-Cobas,Miguel Angel Maestro,Rachel E. Jennings,Lorenzo Pasquali,Lorenzo Pasquali,Ignasi Moran,Natalia Castro,Neil A. Hanley,Neil A. Hanley,José Luis Gómez-Skarmeta,Ludovic Vallier,Ludovic Vallier,Jorge Ferrer,Jorge Ferrer +22 more
TL;DR: A central role is uncovered for TEAD and its coactivator YAP as signal-responsive regulators of multipotent pancreatic progenitors, and this work provides a resource for the study of embryonic development of the human pancreas.
Journal ArticleDOI
Human pancreatic islet three-dimensional chromatin architecture provides insights into the genetics of type 2 diabetes
Irene Miguel-Escalada,Sílvia Bonàs-Guarch,Inês Cebola,Joan Ponsa-Cobas,Julen Mendieta-Esteban,Goutham Atla,Biola M. Javierre,Delphine M.Y. Rolando,Irene Farabella,Claire Morgan,Javier García-Hurtado,Anthony Beucher,Ignasi Moran,Ignasi Moran,Lorenzo Pasquali,Mireia Ramos-Rodríguez,Emil V. R. Appel,Allan Linneberg,Allan Linneberg,Anette P. Gjesing,Daniel R. Witte,Ole Birger Pedersen,Niels Grarup,Philippe Ravassard,David Torrents,David Torrents,Josep M. Mercader,Josep M. Mercader,Josep M. Mercader,Lorenzo Piemonti,Thierry Berney,Eelco J.P. de Koning,Julie Kerr-Conte,François Pattou,Iryna O. Fedko,Iryna O. Fedko,Leif Groop,Inga Prokopenko,Inga Prokopenko,Torben Hansen,Marc A. Marti-Renom,Peter Fraser,Peter Fraser,Jorge Ferrer +43 more
TL;DR: Human islet 3D chromatin architecture provides a framework for interpretation of T2D genome-wide association study (GWAS) signals and identifies more than 1,300 three-dimensional regulatory hubs, linking diabetes-associated enhancers to their target genes.