A
Andrew Berry
Researcher at University of Manchester
Publications - 45
Citations - 3245
Andrew Berry is an academic researcher from University of Manchester. The author has contributed to research in topics: Glucocorticoid receptor & Transactivation. The author has an hindex of 28, co-authored 45 publications receiving 2761 citations. Previous affiliations of Andrew Berry include Central Manchester University Hospitals NHS Foundation Trust & Manchester Academic Health Science Centre.
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Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.
Journal ArticleDOI
Phenotypic and functional analyses show stem cell-derived hepatocyte-like cells better mimic fetal rather than adult hepatocytes
Melissa A. Baxter,Sarah L. Withey,Sean Harrison,Charis-Patricia Segeritz,Charis-Patricia Segeritz,Fang Zhang,Rebecca Atkinson-Dell,Cliff Rowe,Cliff Rowe,Dave T. Gerrard,Rowena Sison-Young,Roz Jenkins,Joanne Henry,Andrew Berry,Lisa Mohamet,Marie Best,Stephen W. Fenwick,Hassan Malik,Neil R. Kitteringham,Christopher E. Goldring,Karen Piper Hanley,Ludovic Vallier,Ludovic Vallier,Neil A. Hanley,Neil A. Hanley +24 more
TL;DR: In this article, the authors generated HLCs from multiple lineages, using two different protocols, for direct comparison with fresh fetal and adult hepatocytes, and found that HLC maturity was proven by transcript, protein and function to be fetal-like and short of the adult phenotype.
Journal ArticleDOI
Human pancreas development
Rachel E. Jennings,Andrew Berry,James P. Strutt,David T. Gerrard,Neil A. Hanley,Neil A. Hanley +5 more
TL;DR: A human-centric view of the latest advances in the authors' understanding of pancreas development is presented and the relevance of these insights from a clinical perspective is discussed.
Journal ArticleDOI
Development of the Human Pancreas From Foregut to Endocrine Commitment
Rachel E. Jennings,Andrew Berry,Rebecca Kirkwood-Wilson,Neil A. Roberts,Tom Hearn,Rachel J. Salisbury,Jennifer Blaylock,Karen Piper Hanley,Neil A. Hanley,Neil A. Hanley +9 more
TL;DR: The expression profiles of key lineage-specific markers are studied to understand differentiation and morphogenetic events during human pancreas development and are anticipated to provide a useful reference point for stem cell researchers looking to differentiate human PSCs in vitro toward the pancreatic β-cell so as to model human development or enable drug discovery and potential cell therapy.
Journal ArticleDOI
Perrault Syndrome Is Caused by Recessive Mutations in CLPP, Encoding a Mitochondrial ATP-Dependent Chambered Protease
Emma M. Jenkinson,Atteeq U. Rehman,Tom Walsh,Jill Clayton-Smith,Kwanghyuk Lee,Robert J. Morell,Meghan C. Drummond,Shaheen N. Khan,Muhammad Asif Naeem,Bushra Rauf,Neil Billington,Julie M. Schultz,Jill E. Urquhart,Ming K. Lee,Andrew Berry,Neil A. Hanley,Sarju G. Mehta,Deirdre D. Cilliers,Peter E. Clayton,Helen Kingston,Miriam J. Smith,Thomas T. Warner,Graeme C.M. Black,Dorothy Trump,Julian R. E. Davis,Wasim Ahmad,Suzanne M. Leal,Sheikh Riazuddin,Sheikh Riazuddin,Mary Claire King,Thomas B. Friedman,William G. Newman +31 more
TL;DR: Together with the previous identification of mutations in HARS2, encoding mitochondrial histidyl-tRNA synthetase, mutations in CLPP expose dysfunction of mitochondrial protein homeostasis as a cause of Perrault syndrome.