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Nikolina Nakic
Researcher at Imperial College London
Publications - 12
Citations - 904
Nikolina Nakic is an academic researcher from Imperial College London. The author has contributed to research in topics: T cell & Cytokine. The author has an hindex of 9, co-authored 12 publications receiving 668 citations. Previous affiliations of Nikolina Nakic include Beta.
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Journal ArticleDOI
Human β Cell Transcriptome Analysis Uncovers lncRNAs That Are Tissue-Specific, Dynamically Regulated, and Abnormally Expressed in Type 2 Diabetes
Ignasi Moran,Ildem Akerman,Martijn van de Bunt,Martijn van de Bunt,Ruiyu Xie,Marion Benazra,Takao Nammo,Luis Arnes,Nikolina Nakic,Javier García-Hurtado,Santiago A. Rodríguez-Seguí,Lorenzo Pasquali,Claire Sauty-Colace,Anthony Beucher,Raphael Scharfmann,Joris van Arensbergen,Paul Johnson,Paul Johnson,Andrew Berry,Clarence Lee,Timothy T. Harkins,Valery Gmyr,François Pattou,Julie Kerr-Conte,Lorenzo Piemonti,Thierry Berney,Neil A. Hanley,Anna L. Gloyn,Lori Sussel,Linda Langman,Kenneth L. Brayman,Maike Sander,Mark I. McCarthy,Mark I. McCarthy,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +36 more
TL;DR: A comprehensive strand-specific transcriptome map of human pancreatic islets and β cells is reported, and a new class of islet-cell genes relevant to β cell programming and diabetes pathophysiology are revealed.
Journal ArticleDOI
Human Pancreatic β Cell lncRNAs Control Cell-Specific Regulatory Networks
Ildem Akerman,Ildem Akerman,Zhidong Tu,Anthony Beucher,Delphine M.Y. Rolando,Claire Sauty-Colace,Marion Benazra,Nikolina Nakic,Jialiang Yang,Huan Wang,Lorenzo Pasquali,Ignasi Moran,Javier García-Hurtado,Natalia Castro,Roser Gonzalez-Franco,Andrew F. Stewart,Caroline Bonner,Lorenzo Piemonti,Thierry Berney,Leif Groop,Julie Kerr-Conte,François Pattou,Carmen Argmann,Eric E. Schadt,Philippe Ravassard,Jorge Ferrer,Jorge Ferrer +26 more
TL;DR: It is demonstrated that the lncRNA PLUTO affects local 3D chromatin structure and transcription of PDX1, encoding a key β cell transcription factor, and that bothPLUTO andPDX1 are downregulated in islets from donors with type 2 diabetes or impaired glucose tolerance.
Journal ArticleDOI
Single-cell transcriptomics identifies an effectorness gradient shaping the response of CD4+ T cells to cytokines
Eddie Cano-Gamez,Blagoje Soskic,Theodoros I. Roumeliotis,Ernest C. So,Deborah J. Smyth,Marta Baldrighi,David R. Willé,Nikolina Nakic,Jorge Esparza-Gordillo,Christopher G. C. Larminie,Paola G. Bronson,David F. Tough,Wendy C. Rowan,Jyoti S. Choudhary,Gosia Trynka +14 more
TL;DR: It is shown that naïve and memory T cells exhibit distinct cytokine responses, in which an ‘effectorness gradient’ is depicted by a transcriptional continuum, which shapes the downstream genetic programs.
Journal ArticleDOI
Chromatin activity at GWAS loci identifies T cell states driving complex immune diseases.
Blagoje Soskic,Eddie Cano-Gamez,Deborah J. Smyth,Wendy C. Rowan,Nikolina Nakic,Jorge Esparza-Gordillo,Lara Bossini-Castillo,David F. Tough,Christopher G. C. Larminie,Paola G. Bronson,David R. Willé,Gosia Trynka +11 more
TL;DR: Integration of immune-disease GWAS variants with open chromatin and enhancer profiling in T cells and macrophages stimulated with different cytokines and analyzed at different time points reveals cell-state-specific enrichments for 12 complex diseases.
Posted ContentDOI
Human pancreatic β cell lncRNAs control cell-specific regulatory networks
Ildem Akerman,Zhidong Tu,Anthony Beucher,Delphine M.Y. Rolando,Claire Sauty-Colace,Marion Benazra,Nikolina Nakic,Jialiang Yang,Huan Wang,Lorenzo Pasquali,Ignasi Moran,Javier García-Hurtado,Natalia Castro,Roser Gonzalez-Franco,Andrew F. Stewart,Caroline Bonner,Lorenzo Piemonti,Thierry Berney,Leif Groop,Julie Kerr-Conte,François Pattou,Carmen Argmann,Eric E. Schadt,Philippe Ravassard,Jorge Ferrer +24 more
TL;DR: It is demonstrated that lncRNAs that function in concert with transcription factors to regulate β cell-specific transcriptional networks affect local three-dimensional chromatin structure and transcription of PDX1, encoding a key β cell transcription factor.