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Nicholas J. Bernard
Researcher at Walter and Eliza Hall Institute of Medical Research
Publications - 84
Citations - 3826
Nicholas J. Bernard is an academic researcher from Walter and Eliza Hall Institute of Medical Research. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 15, co-authored 66 publications receiving 3117 citations. Previous affiliations of Nicholas J. Bernard include University of Melbourne & Trinity College, Dublin.
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Journal ArticleDOI
Succinate is an inflammatory signal that induces IL-1β through HIF-1α
Gillian M. Tannahill,Anne M. Curtis,Juraj Adamik,Eva M. Palsson-McDermott,Anne F. McGettrick,Gautam Goel,Christian Frezza,Nicholas J. Bernard,Beth Kelly,Niamh Foley,Liang Zheng,A. Gardet,Zhen Tong,S. S. Jany,Sinéad C. Corr,Moritz Haneklaus,Brian E. Caffrey,Kerry A. Pierce,Sarah R. Walmsley,F. C. Beasley,Eoin P. Cummins,Victor Nizet,Moira K. B. Whyte,Cormac T. Taylor,Hening Lin,Seth L. Masters,Eyal Gottlieb,Vincent P. Kelly,Clary B. Clish,Philip E. Auron,Ramnik J. Xavier,Ramnik J. Xavier,Luke A. J. O'Neill +32 more
TL;DR: The authors showed that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macrophages.
Journal ArticleDOI
IP-10-mediated T cell homing promotes cerebral inflammation over splenic immunity to malaria infection.
Catherine Q Nie,Nicholas J. Bernard,M. Ursula Norman,Fiona H. Amante,Rachel J. Lundie,Brendan S. Crabb,William R. Heath,Christian R. Engwerda,Michael J. Hickey,Louis Schofield,Diana S. Hansen +10 more
TL;DR: The results demonstrate that modulating homing of cellular immune responses to malaria is critical for reaching a balance between protective immunity and immunopathogenesis and demonstrate that lack of IP-10 during infection significantly reduces peripheral parasitemia.
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Association of Early Interferon-γ Production with Immunity to Clinical Malaria: A Longitudinal Study among Papua New Guinean Children
Marthe C. D'Ombrain,Marthe C. D'Ombrain,Leanne J. Robinson,Leanne J. Robinson,Danielle I. Stanisic,Jack Taraika,Nicholas J. Bernard,Pascal Michon,Ivo Mueller,Louis Schofield +9 more
TL;DR: High, early IFN-gamma production by live parasite-stimulated peripheral blood mononuclear cells is a correlate of immunity to symptomatic malaria in Papua New Guinean children, and natural killer-like gammadelta T cells may contribute to protection.
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NK cells stimulate recruitment of CXCR3+ T cells to the brain during Plasmodium berghei-mediated cerebral malaria.
TL;DR: It is shown that NK cells are required for cerebral malaria disease induction and the control of parasitemia, and this chemokine pathway plays an essential role in leukocyte trafficking leading to cerebral disease and fatalities.
Journal ArticleDOI
A role for Blimp1 in the transcriptional network controlling natural killer cell maturation.
Axel Kallies,Sebastian Carotta,Nicholas D. Huntington,Nicholas J. Bernard,David M. Tarlinton,Mark J. Smyth,Stephen L. Nutt +6 more
TL;DR: NK cells are identified as the first hematopoietic cell type in which the IRF4-Blimp1-Bcl6 regulatory axis is not in operation, highlighting the distinct nature of the NK-cell gene-regulatory network.