Sheena Gupta

TL;DR: In this article, the authors used a system vaccinology approach to comprehensively profile the innate and adaptive immune responses of 56 healthy volunteers who were vaccinated with the Pfizer-BioNTech mRNA vaccine (BNT162b2).

TL;DR: Sustained success is associated with the induction, expansion, and maintenance of immunotherapy-specific memory and naive T-cell phenotypes as early as 3 mo into immunotherapy, suggesting an approach for immune monitoring participants undergoing immunotherapy to predict the success of future treatment.

TL;DR: Blood samples collected in heparin tubes were adequate for quantification of upregulation of basophil CD203c and identification of a population of CD63hi basophils, irrespective of whether the specimens were analyzed by means of conventional flow cytometry or cytometry by time‐of‐flight mass spectrometry, and such tests could be performed after blood was stored for 24 hours at 4°C.

TL;DR: CD85j characterizes a population of “senescent,” but not exhausted antigen-specific effector CD8 T cells and indicates that CD85j is an important checkpoint regulator controlling expansion of virus-specific T cells during aging.

TL;DR: Transmembrane and cytoplasmic domains of MOG contain immunodominant T-cell epitopes in EAE, indicating that a myelin antigen contains multiple encephalitogenic and nonencephalitogenic determinants may have implications for therapeutic development in MS.