N
Nik Sol
Researcher at VU University Medical Center
Publications - 22
Citations - 1365
Nik Sol is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Medicine & Cancer. The author has an hindex of 10, co-authored 15 publications receiving 922 citations. Previous affiliations of Nik Sol include University of Amsterdam.
Papers
More filters
Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Effects of the Selective MPS1 Inhibitor MPS1-IN-3 on Glioblastoma Sensitivity to Antimitotic Drugs
Bakhos A. Tannous,Mariam Kerami,Petra van der Stoop,Nicholas Kwiatkowski,Jinhua Wang,Wenjun Zhou,Almuth F. Kessler,Grant K. Lewandrowski,Lotte Hiddingh,Nik Sol,Tonny Lagerweij,Laurine E. Wedekind,Johanna M. Niers,Marco Barazas,R. Jonas A. Nilsson,Dirk Geerts,Philip C. De Witt Hamer,Carsten Hagemann,W. Peter Vandertop,Olaf van Tellingen,David P. Noske,Nathanael S. Gray,Thomas Wurdinger +22 more
TL;DR: It is demonstrated that MPS1, a putative therapeutic target in glioblastoma, can be selectively inhibited by M PS1-IN-3 sensitizing gliOBlastoma cells to antimitotic drugs.
Journal ArticleDOI
RNA sequencing and swarm intelligence–enhanced classification algorithm development for blood-based disease diagnostics using spliced blood platelet RNA
TL;DR: The wet-lab protocol for the generation of platelet RNA-sequencing libraries and the dry-lab Protocol for the development of swarm intelligence–enhanced machine-learning-based classification algorithms are provided to enable the scientific community to test plateletRNA for diagnostic algorithm development.
Journal ArticleDOI
Liquid biopsies in patients with diffuse glioma
Myron G. Best,Nik Sol,Sebastiaan Zijl,Jaap C. Reijneveld,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger +6 more
TL;DR: The literature on blood-based biomarkers and their potential value for improving the management of patients with a diffuse glioma is summarized and incorporation of the study of circulating molecular biomarkers in clinical trials is essential.