J
Johanna M. Niers
Researcher at Harvard University
Publications - 18
Citations - 1725
Johanna M. Niers is an academic researcher from Harvard University. The author has contributed to research in topics: Glioma & Regulation of gene expression. The author has an hindex of 14, co-authored 16 publications receiving 1391 citations. Previous affiliations of Johanna M. Niers include VU University Amsterdam & VU University Medical Center.
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Journal ArticleDOI
Human Glioma Growth is Controlled by MicroRNA-10b
Galina Gabriely,Ming Yi,Ravi S. Narayan,Johanna M. Niers,Thomas Wurdinger,Jaime Imitola,Keith L. Ligon,Santosh Kesari,Christine Esau,Robert M. Stephens,Bakhos A. Tannous,Anna M. Krichevsky +11 more
TL;DR: It is shown that inhibition of miR-10b, a miRNA not expressed in human brain and strongly upregulated in both low-grade and high-grade gliomas, reduces glioma cell growth by cell-cycle arrest and apoptosis, and suggests the possibility of its future use as a therapeutic target ingliomas.
Journal ArticleDOI
Longitudinal molecular trajectories of diffuse glioma in adults
Floris P. Barthel,Kevin C. Johnson,Frederick S. Varn,Anzhela D. Moskalik,Georgette Tanner,Emre Kocakavuk,Kevin J. Anderson,Olajide Abiola,Kenneth Aldape,Kristin Alfaro,Donát Alpár,Donát Alpár,Samirkumar B. Amin,David M. Ashley,Pratiti Bandopadhayay,Pratiti Bandopadhayay,Jill S. Barnholtz-Sloan,Rameen Beroukhim,Rameen Beroukhim,Christoph Bock,Christoph Bock,Priscilla K. Brastianos,Daniel J. Brat,Andrew R Brodbelt,Alexander F. Bruns,Ketan R. Bulsara,Aruna Chakrabarty,Arnab Chakravarti,Jeffrey H. Chuang,Elizabeth B. Claus,Elizabeth B. Claus,Elizabeth J. Cochran,Jennifer Connelly,Joseph F. Costello,Gaetano Finocchiaro,Michael N. C. Fletcher,Pim J. French,Hui K Gan,Hui K Gan,Mark R. Gilbert,Peter Gould,Matthew R. Grimmer,Antonio Iavarone,Azzam Ismail,Michael D. Jenkinson,Mustafa Khasraw,Hoon Kim,Mathilde C.M. Kouwenhoven,Peter S. LaViolette,Meihong Li,Peter Lichter,Keith L. Ligon,Keith L. Ligon,Allison Lowman,Tathiane M. Malta,Tali Mazor,Kerrie L. McDonald,Annette M. Molinaro,Do-Hyun Nam,Naema Nayyar,Ho Keung Ng,Chew Yee Ngan,Simone P. Niclou,Johanna M. Niers,Houtan Noushmehr,Javad Noorbakhsh,D. Ryan Ormond,Chul-Kee Park,Laila M. Poisson,Raul Rabadan,Raul Rabadan,Bernhard Radlwimmer,Ganesh Rao,Guido Reifenberger,Jason K. Sa,Michael Schuster,Brian L. Shaw,Susan C Short,Peter A. E. Sillevis Smitt,Andrew E. Sloan,Andrew E. Sloan,Marion Smits,Hiromichi Suzuki,Ghazaleh Tabatabai,Erwin G. Van Meir,Colin Watts,Michael Weller,Pieter Wesseling,Bart A. Westerman,Georg Widhalm,Adelheid Woehrer,W. K. Alfred Yung,Gelareh Zadeh,Jason T. Huse,John de Groot,Lucy F. Stead,Roel G.W. Verhaak +96 more
TL;DR: The results suggest that the strongest selective pressures occur during early glioma development and that current therapies shape this evolution in a largely stochastic manner.
Journal ArticleDOI
In Silico Analysis of Kinase Expression Identifies WEE1 as a Gatekeeper against Mitotic Catastrophe in Glioblastoma
Shahryar E. Mir,Philip C. De Witt Hamer,Przemek M. Krawczyk,Leonora Balaj,An Claes,Johanna M. Niers,Johanna M. Niers,Angela A.G. van Tilborg,Aeilko H. Zwinderman,Dirk Geerts,Gertjan J.L. Kaspers,W. Peter Vandertop,Jacqueline Cloos,Bakhos A. Tannous,Pieter Wesseling,Jacob A. Aten,David P. Noske,Cornelis J.F. Van Noorden,Thomas Wurdinger,Thomas Wurdinger +19 more
TL;DR: It is demonstrated that WEE1 is a major regulator of the G(2) checkpoint in glioblastoma cells, and it is shown that the small-molecule inhibitor of Wee1 sensitizes gliOBlastoma to ionizing radiation in vivo.
Journal ArticleDOI
miR-101 is down-regulated in glioblastoma resulting in EZH2-induced proliferation, migration, and angiogenesis
Michiel Smits,Jonas Nilsson,Shahryar E. Mir,Petra van der Stoop,Esther Hulleman,Johanna M. Niers,Phillip C. de Witt Hamer,Victor E. Marquez,Jacqueline Cloos,Anna M. Krichevsky,David P. Noske,Bakhos A. Tannous,Thomas Wurdinger +12 more
TL;DR: The results indicate that EZH2 has a versatile function in GBM progression and that its overexpression is at least partly due to decreased miR-101 expression, which may be a potential therapeutic strategy to target GBM proliferation, migration, and angiogenesis.
Journal ArticleDOI
Down-regulation of miR-101 in endothelial cells promotes blood vessel formation through reduced repression of EZH2.
Michiel Smits,Shahryar E. Mir,R. Jonas A. Nilsson,Petra van der Stoop,Johanna M. Niers,Johanna M. Niers,Victor E. Marquez,Jacqueline Cloos,Xandra O. Breakefield,Anna M. Krichevsky,David P. Noske,Bakhos A. Tannous,Thomas Wurdinger,Thomas Wurdinger +13 more
TL;DR: By identifying a pro-angiogenic VEGF/miR-101/EZH2 axis in endothelial cells, this work provides evidence for a functional link between growth factor-mediated signaling, post-transcriptional silencing, and histone-methylation in the angiogenesis process.