H
Heleen Verschueren
Researcher at VU University Medical Center
Publications - 5
Citations - 933
Heleen Verschueren is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Cancer & Gene. The author has an hindex of 3, co-authored 3 publications receiving 633 citations.
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Journal ArticleDOI
RNA-Seq of Tumor-Educated Platelets Enables Blood-Based Pan-Cancer, Multiclass, and Molecular Pathway Cancer Diagnostics
Myron G. Best,Nik Sol,Irsan E. Kooi,Jihane Tannous,Bart A. Westerman,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Jan Koster,Bauke Ylstra,Najim Ameziane,Josephine C. Dorsman,Egbert F. Smit,Henk M.W. Verheul,David P. Noske,Jaap C. Reijneveld,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Pieter Wesseling,Thomas Wurdinger,Thomas Wurdinger +23 more
TL;DR: The results indicate that blood platelets provide a valuable platform for pan-cancer, multiclass cancer, and companion diagnostics, possibly enabling clinical advances in blood-based “liquid biopsies”.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Tumor-Educated Platelet RNA for the Detection and (Pseudo)progression Monitoring of Glioblastoma
Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Maud Tjerkstra,Cyra E. Leurs,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Kenn Zwaan,Jip Ramaker,Laurine E. Wedekind,Jihane Tannous,Bauke Ylstra,Joep Killestein,Farrah J. Mateen,Sander Idema,Philip C. De Witt Hamer,Anna C. Navis,William P.J. Leenders,Ann Hoeben,B. Moraal,David P. Noske,W. Peter Vandertop,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Bakhos A. Tannous,Pieter Wesseling,Jaap C. Reijneveld,Myron G. Best,Thomas Wurdinger +30 more
TL;DR: Tumor-educated platelets (TEPs) have potential as a minimally invasive biosource for blood-based diagnostics and monitoring of glioblastoma patients and could be used to distinguish false positive progression from true progression.
Journal ArticleDOI
Detection and localization of early- and late-stage cancers using platelet RNA.
Sjors G J G In 't Veld,Mohammad Arkani,Edward Post,Mafalda Antunes-Ferreira,Silvia D’Ambrosi,Daan C L Vessies,Lisa Vermunt,Adrienne Vancura,Mirte Muller,Anna-Larissa N. Niemeijer,Jihane Tannous,Laura L. Meijer,Tessa Y S Le Large,Giulia Mantini,Niels Wondergem,K.M. Heinhuis,Sandra van Wilpe,A.J. Smits,Esther E.E. Drees,Eva Roos,Cyra E. Leurs,Lee Ann Tjon Kon Fat,Ewoud J. van der Lelij,Govert Dwarshuis,Maarten J. Kamphuis,Lisanne E Visser,Romée Harting,Annemijn Gregory,Markus Schweiger,Laurine E. Wedekind,J. Ramaker,Kenn Zwaan,Heleen Verschueren,Idris Bahce,Adrianus J. de Langen,Egbert F. Smit,Michel M. van den Heuvel,Koen J. Hartemink,Marijke J.E. Kuijpers,Mirjam G.A. oude Egbrink,Arjan W. Griffioen,R.L. Rossel,T. Jeroen N. Hiltermann,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Philip C. De Witt Hamer,Mathilde C.M. Kouwenhoven,Jaap C. Reijneveld,William P.J. Leenders,Ann Hoeben,Irma M. Verdonck-de Leeuw,C. René Leemans,Robert J. Baatenburg de Jong,Chris H.J. Terhaard,Robert P. Takes,Johannes A. Langendijk,Saskia C.A. de Jager,Adriaan O. Kraaijeveld,Gerard Pasterkamp,Minke Smits,Jack A. Schalken,Sylwia Łapińska-Szumczyk,Anna Łojkowska,Anna J. Zaczek,Henk M. Lokhorst,N. W. C. J. van de Donk,Inger S. Nijhof,Henk-Jan Prins,Josée M. Zijlstra,Sander Idema,Johannes C. Baayen,Charlotte E. Teunissen,Joep Killestein,Marc G. Besselink,Lindsay Brammen,Thomas Bachleitner-Hofmann,Farrah J. Mateen,John T. M. Plukker,Michal Heger,Quirijn de Mast,Ton Lisman,D. Michiel Pegtel,Harm Jan Bogaard,Jacek Jassem,Anna Supernat,Niven Mehra,Winald R. Gerritsen,Cornelis D. de Kroon,Christianne A. R. Lok,Jürgen Piek,Neeltje Steeghs,Winan J. van Houdt,Ruud H. Brakenhoff,Gabe S. Sonke,Henk M.W. Verheul,Elisa Giovannetti,Geert Kazemier,Siamack Sabrkhany,Ed Schuuring,Erik A. Sistermans,Rob M. F. Wolthuis,Hanne Meijers-Heijboer,Josephine C. Dorsman,Cees B.M. Oudejans,Bauke Ylstra,Bart A. Westerman,D. Van Den Broek,Danijela Koppers-Lalic,Pieter Wesseling,R. Jonas A. Nilsson,W. Peter Vandertop,David P. Noske,Bakhos A. Tannous,Nik Sol,Myron G. Best,Thomas Wurdinger +115 more
TL;DR: In this article , a tumor-educated platelet (TEP) RNA-based blood tests enable the detection of 18 cancer types with 99% specificity in asymptomatic controls.
Journal ArticleDOI
ALL-tRNAseq enables robust tRNA profiling in tissue samples.
Chantal Scheepbouwer,Ernesto Aparicio-Puerta,Cristina Gómez-Martín,Heleen Verschueren,Monique A. J. van Eijndhoven,Laurine E. Wedekind,Stavros Giannoukakos,Nathalie J. Hijmering,Lisa Gasparotto,Hilde T van der Galien,Roos S. van Rijn,Eleonora Aronica,Robby E. Kibbelaar,Vivi M. Heine,Pieter Wesseling,David P. Noske,W. Peter Vandertop,Daphne de Jong,D. Michiel Pegtel,Michael Hackenberg,Thomas Wurdinger,Alan Gerber,Danijela Koppers-Lalic +22 more
TL;DR: The ALL-tRNAseq method as mentioned in this paper combines the highly processive MarathonRT and RNA demethylation for the robust assessment of tRNA expression, together with a randomized adapter ligation strategy prior to reverse transcription to assess tRNA fragmentation levels in both cell lines and tissues.