C
Cyra E. Leurs
Researcher at VU University Medical Center
Publications - 29
Citations - 1368
Cyra E. Leurs is an academic researcher from VU University Medical Center. The author has contributed to research in topics: Natalizumab & Multiple sclerosis. The author has an hindex of 13, co-authored 28 publications receiving 781 citations. Previous affiliations of Cyra E. Leurs include University of Amsterdam & VU University Amsterdam.
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Journal ArticleDOI
Deep gray matter volume loss drives disability worsening in multiple sclerosis.
Arman Eshaghi,Arman Eshaghi,Ferran Prados,Wallace Brownlee,Daniel R. Altmann,Daniel R. Altmann,Carmen Tur,M. Jorge Cardoso,Floriana De Angelis,Steven Harry Pieter van de Pavert,Niamh Cawley,Nicola De Stefano,M. Laura Stromillo,Marco Battaglini,Serena Ruggieri,Claudio Gasperini,Massimo Filippi,Maria A. Rocca,Alex Rovira,Jaume Sastre-Garriga,Hugo Vrenken,Cyra E. Leurs,Joep Killestein,Lukas Pirpamer,Christian Enzinger,Sebastien Ourselin,Sebastien Ourselin,Claudia A. M. Wheeler-Kingshott,Claudia A. M. Wheeler-Kingshott,Declan T. Chard,Declan T. Chard,Alan J. Thompson,Daniel C. Alexander,Frederik Barkhof,Olga Ciccarelli,Olga Ciccarelli +35 more
TL;DR: This work investigated whether there is a spatiotemporal pattern of GM atrophy that is associated with faster disability accumulation in MS.
Journal ArticleDOI
Progression of regional grey matter atrophy in multiple sclerosis.
Arman Eshaghi,Arman Eshaghi,Razvan V. Marinescu,Alexandra L. Young,Nicholas C. Firth,Ferran Prados,M. Jorge Cardoso,Carmen Tur,Floriana De Angelis,Niamh Cawley,Wallace Brownlee,Nicola De Stefano,M. Laura Stromillo,Marco Battaglini,Serena Ruggieri,Claudio Gasperini,Massimo Filippi,Maria A. Rocca,Alex Rovira,Jaume Sastre-Garriga,Jeroen J. G. Geurts,Hugo Vrenken,Viktor Wottschel,Cyra E. Leurs,Bernard M. J. Uitdehaag,Lukas Pirpamer,Christian Enzinger,Sebastien Ourselin,Sebastien Ourselin,Claudia Am Gandini Wheeler-Kingshott,Claudia Am Gandini Wheeler-Kingshott,Declan T. Chard,Declan T. Chard,Alan J. Thompson,Frederik Barkhof,Daniel C. Alexander,Olga Ciccarelli,Olga Ciccarelli +37 more
TL;DR: A data-driven computational model is used to predict the order in which regions atrophy in multiple sclerosis, and use this sequence to stage patients.
Journal ArticleDOI
Swarm Intelligence-Enhanced Detection of Non-Small-Cell Lung Cancer Using Tumor-Educated Platelets
Myron G. Best,Nik Sol,Sjors G J G In 't Veld,Adrienne Vancura,Mirte Muller,Anna Larissa N. Niemeijer,Aniko V. Fejes,Aniko V. Fejes,Lee Ann Tjon Kon Fat,Anna E. Huis In ‘t Veld,Cyra E. Leurs,Tessa Y S Le Large,Laura L. Meijer,Irsan E. Kooi,François Rustenburg,Pepijn Schellen,Heleen Verschueren,Edward Post,Laurine E. Wedekind,Jillian Bracht,Michelle Esenkbrink,Leon J Wils,Francesca Favaro,Jilian D. Schoonhoven,Jihane Tannous,Hanne Meijers-Heijboer,Geert Kazemier,Elisa Giovannetti,Jaap C. Reijneveld,Sander Idema,Joep Killestein,Michal Heger,Saskia C.A. de Jager,Rolf T. Urbanus,Imo E. Hoefer,Gerard Pasterkamp,Christine Mannhalter,Jose Gomez-Arroyo,Harm Jan Bogaard,David P. Noske,W. Peter Vandertop,Daan van den Broek,Bauke Ylstra,R. Jonas A. Nilsson,R. Jonas A. Nilsson,Pieter Wesseling,Pieter Wesseling,Niki Karachaliou,Rafael Rosell,Elizabeth Lee-Lewandrowski,Kent B. Lewandrowski,Bakhos A. Tannous,Adrianus J. de Langen,Egbert F. Smit,Egbert F. Smit,Michel M van den Heuvel,Michel M van den Heuvel,Thomas Wurdinger,Thomas Wurdinger +58 more
TL;DR: It is demonstrated that particle-swarm optimization-enhanced algorithms enable efficient selection of RNA biomarker panels from platelet RNA-sequencing libraries to diagnose cancer from TEPs, suggesting that swarm intelligence may also benefit the optimization of diagnostics readout of other liquid biopsy biosources.
Journal ArticleDOI
Body fluid biomarkers for multiple sclerosis—the long road to clinical application
TL;DR: Expect biomarker development for MS to be improved and accelerated, with clinical implementation in the near future, in view of the availability and implementation of several standardized protocols to optimize biomarker studies.
Posted ContentDOI
Progression of regional grey matter atrophy in multiple sclerosis
Arman Eshaghi,Razvan V. Marinescu,Alexandra L. Young,Nicholas C. Firth,Ferran Prados,M. Jorge Cardoso,Carmen Tur,Floriana De Angelis,Niamh Cawley,Wallace Brownlee,Nicola De Stefano,M. Laura Stromillo,Marco Battaglini,Serena Ruggieri,Claudio Gasperini,Massimo Filippi,Maria A. Rocca,Alex Rovira,Jaume Sastre-Garriga,Jeroen J. G. Geurts,Hugo Vrenken,Viktor Wottschel,Cyra E. Leurs,Bernard M. J. Uitdehaag,Lukas Pirpamer,Christian Enzinger,Sebastien Ourselin,Claudia Am Gandini Wheeler-Kingshott,Declan T. Chard,Alan J. Thompson,Frederik Barkhof,Daniel C. Alexander,Olga Ciccarelli +32 more
TL;DR: The sequence in which regions become atrophic is reasonably consistent across MS phenotypes, and the spread of atrophy was associated with disease duration, and disability accumulation in RRMS.