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Niklas Norgren
Researcher at Umeå University
Publications - 26
Citations - 4606
Niklas Norgren is an academic researcher from Umeå University. The author has contributed to research in topics: Neurofilament & GFAP stain. The author has an hindex of 22, co-authored 26 publications receiving 3672 citations.
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Journal ArticleDOI
Comparison of three analytical platforms for quantification of the neurofilament light chain in blood samples: ELISA, electrochemiluminescence immunoassay and Simoa
Jens Kuhle,Christian Barro,Ulf Andreasson,Tobias Derfuss,Raija L.P. Lindberg,Åsa Sandelius,Victor Liman,Niklas Norgren,Kaj Blennow,Henrik Zetterberg +9 more
TL;DR: The highly sensitive Simoa technology deserves further studies in larger patient cohorts to clarify whether serum NfL could be used in the future to measure disease severity and determine prognosis or response to treatment interventions in neurological diseases.
Journal ArticleDOI
Neurofilament light chain: A prognostic biomarker in amyotrophic lateral sclerosis.
Ching-Hua Lu,Corrie Macdonald-Wallis,Elizabeth Gray,Neil Pearce,Axel Petzold,Niklas Norgren,Gavin Giovannoni,Pietro Fratta,Katie Sidle,Mark Fish,Richard W. Orrell,Robin S. Howard,Kevin Talbot,Linda Greensmith,Jens Kuhle,Martin R Turner,Andrea Malaspina +16 more
TL;DR: This report provides Class III evidence that the NfL electrochemiluminescence immunoassay accurately distinguishes patients with sporadic ALS from healthy controls and offers potential for N fL as a pharmacodynamic biomarker in future therapeutic trials.
Journal ArticleDOI
Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases
Johanna Gaiottino,Niklas Norgren,Ruth Dobson,Joanne Topping,Ahuva Nissim,Andrea Malaspina,Jonathan P. Bestwick,Andreas U. Monsch,Axel Regeniter,Raija L.P. Lindberg,Ludwig Kappos,David Leppert,Axel Petzold,Gavin Giovannoni,Jens Kuhle,Jens Kuhle +15 more
TL;DR: The data supports further longitudinal studies of serum NfL in neurodegenerative diseases as a potential biomarker of on-going disease progression, and as a possible surrogate to quantify effects of neuroprotective drugs in clinical trials.
Journal ArticleDOI
Plasma Concentration of the Neurofilament Light Protein (NFL) is a Biomarker of CNS Injury in HIV Infection: A Cross-Sectional Study
Magnus Gisslén,Richard W. Price,Ulf Andreasson,Niklas Norgren,Staffan Nilsson,Lars Hagberg,Dietmar Fuchs,Serena Spudich,Kaj Blennow,Henrik Zetterberg,Henrik Zetterberg +10 more
TL;DR: Results show that plasma NFL may prove a valuable tool to evaluate ongoing CNS injury in HIV infection that may be applied in the clinic and in research settings to assess the presence if active CNS injury.
Journal ArticleDOI
Serum neurofilament light chain protein is a measure of disease intensity in frontotemporal dementia
Jonathan D. Rohrer,Ione O.C. Woollacott,Katrina M. Dick,Emilie V. Brotherhood,Elizabeth Gordon,Alexander D. Fellows,Jamie Toombs,Ronald Druyeh,M. Jorge Cardoso,Sebastien Ourselin,Jennifer M. Nicholas,Niklas Norgren,Simon Mead,Ulf Andreasson,Kaj Blennow,Jonathan M. Schott,Nick C. Fox,Jason D. Warren,Henrik Zetterberg +18 more
TL;DR: Higher concentrations may reflect the intensity of the disease in FTD and are associated with more rapid atrophy of the frontal lobes and show wide variability within each clinical and genetic group.