R
Ruth Dobson
Researcher at Queen Mary University of London
Publications - 176
Citations - 5112
Ruth Dobson is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Medicine & Multiple sclerosis. The author has an hindex of 26, co-authored 116 publications receiving 3351 citations. Previous affiliations of Ruth Dobson include Manchester Academic Health Science Centre & Royal London Hospital.
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Journal ArticleDOI
Multiple Sclerosis - A Review
Ruth Dobson,Gavin Giovannoni +1 more
TL;DR: The epidemiology of MS indicates that low serum levels of vitamin D, smoking, childhood obesity and infection with the Epstein–Barr virus are likely to play a role in disease development, and potentially preventive strategies could be studied.
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Multiple sclerosis: risk factors, prodromes, and potential causal pathways
TL;DR: Identifying and studying individuals with a high risk of developing the disease provides a powerful opportunity to understand the MS causal cascade and is highly relevant to strategies that are aimed at preventing this debilitating disease.
Journal ArticleDOI
Increased Neurofilament Light Chain Blood Levels in Neurodegenerative Neurological Diseases
Johanna Gaiottino,Niklas Norgren,Ruth Dobson,Joanne Topping,Ahuva Nissim,Andrea Malaspina,Jonathan P. Bestwick,Andreas U. Monsch,Axel Regeniter,Raija L.P. Lindberg,Ludwig Kappos,David Leppert,Axel Petzold,Gavin Giovannoni,Jens Kuhle,Jens Kuhle +15 more
TL;DR: The data supports further longitudinal studies of serum NfL in neurodegenerative diseases as a potential biomarker of on-going disease progression, and as a possible surrogate to quantify effects of neuroprotective drugs in clinical trials.
Journal ArticleDOI
Cerebrospinal fluid oligoclonal bands in multiple sclerosis and clinically isolated syndromes: a meta-analysis of prevalence, prognosis and effect of latitude
TL;DR: OCB positivity strongly predicts conversion from CIS to MS, and the relationship between latitude and OCBs is confirmed, and this finding warrants further investigation.
Journal ArticleDOI
Conversion from clinically isolated syndrome to multiple sclerosis: A large multicentre study
Jens Kuhle,Giulio Disanto,Ruth Dobson,Rocco Adiutori,Lucia Bianchi,Joanne Topping,Jonathan P. Bestwick,Ute-Christiane Meier,Monica Marta,G. Dalla Costa,Tessel F. Runia,E. P. Evdoshenko,N. Lazareva,Eric Thouvenot,Pietro Iaffaldano,Vita Direnzo,Mohsen Khademi,Fredrik Piehl,Manuel Comabella,Madeleine H. Sombekke,Joep Killestein,Harald Hegen,Scott L. Rauch,Sandra D'Alfonso,José C. Álvarez-Cermeño,P. Kleinova,Dana Horakova,Romy Roesler,Florian Lauda,Sara Llufriu,Timucin Avsar,Ugur Uygunoglu,Ayse Altintas,S. Saip,Til Menge,Cecilia Rajda,Roberto Bergamaschi,N. Moll,Michael Khalil,Romain Marignier,Irena Dujmovic,Henrik Larsson,Clas Malmeström,Elio Scarpini,Chiara Fenoglio,Stig Wergeland,Alice Laroni,Viviana Annibali,Silvia Romano,A.D. Martinez,Adriana Carrá,Marco Salvetti,Antonio Uccelli,Øivind Torkildsen,Kjell-Morten Myhr,Daniela Galimberti,Konrad Rejdak,Jan Lycke,Jette L. Frederiksen,Jelena Drulovic,Christian Confavreux,David Brassat,Christian Enzinger,Siegrid Fuchs,Isabel Bosca,Jean Pelletier,C. Picard,E. Colombo,Diego Franciotta,Tobias Derfuss,Raija L.P. Lindberg,Özgür Yaldizli,László Vécsei,B. C. Kieseier,H.-P. Hartung,Pablo Villoslada,Aksel Siva,Albert Saiz,Hayrettin Tumani,Eva Havrdova,Luisa M. Villar,Maurizio Leone,N. Barizzone,Florian Deisenhammer,Charlotte E. Teunissen,Xavier Montalban,Mar Tintoré,Tomas Olsson,Maria Trojano,Sylvain Lehmann,Giovanni Castelnovo,Sergey V. Lapin,Rogier Q. Hintzen,Ludwig Kappos,Roberto Furlan,Vittorio Martinelli,G. Comi,Sreeram V. Ramagopalan,Gavin Giovannoni +98 more
TL;DR: MRI lesion load, OCB and age at CIS are validated as the strongest independent predictors of conversion to CDMS in this multicentre setting.