T
Tim Van Acker
Researcher at Francis Crick Institute
Publications - 11
Citations - 728
Tim Van Acker is an academic researcher from Francis Crick Institute. The author has contributed to research in topics: Autophagy & Endocytosis. The author has an hindex of 10, co-authored 11 publications receiving 589 citations. Previous affiliations of Tim Van Acker include Ghent University.
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Journal ArticleDOI
The need for transparency and good practices in the qPCR literature
Stephen A. Bustin,Vladimir Benes,Jeremy A. Garson,Jan Hellemans,Jim F. Huggett,Mikael Kubista,Reinhold Mueller,Tania Nolan,Michael W. Pfaffl,Gregory L. Shipley,Carl T. Wittwer,Peter Schjerling,Philip J. R. Day,Mónica Abreu,Begoña Aguado,Jean-François Beaulieu,Anneleen Beckers,Sara Bogaert,John A. Browne,Fernando Carrasco-Ramiro,Liesbeth Ceelen,Kate L. Ciborowski,Pieter Cornillie,Stephanie Coulon,Ann Cuypers,Sara De Brouwer,Leentje De Ceuninck,Jurgen De Craene,Hélène De Naeyer,Ward De Spiegelaere,Kato Deckers,Annelies Dheedene,Kaat Durinck,Margarida Ferreira-Teixeira,Annelies Fieuw,Jack M. Gallup,Sandra Gonzalo-Flores,Karen Goossens,Femke Heindryckx,Elizabeth Herring,Hans Hoenicka,Laura Icardi,Rolf Jaggi,Farzad Javad,Michael Karampelias,Frederick S. B. Kibenge,Molly J. T. Kibenge,Candy Kumps,Irina Lambertz,Tim Lammens,Amelia Markey,Peter Messiaen,Evelien Mets,Sofia Morais,Alberto Mudarra-Rubio,Justine K. Nakiwala,Hilde Nelis,Pål A. Olsvik,Claudina Perez-Novo,Michelle Plusquin,Tony Remans,Ali Rihani,Paulo Rodrigues-Santos,Pieter Rondou,Rebecca Sanders,Katharina Schmidt-Bleek,Kerstin Skovgaard,Karen Smeets,Laura Tabera,Stefan Toegel,Tim Van Acker,Wim Van den Broeck,Joni Van der Meulen,Mireille Van Gele,Gert Van Peer,Mario Van Poucke,Nadine Van Roy,Sarah Vergult,Joris Wauman,Marina Tshuikina-Wiklander,Erik Willems,Sara Zaccara,Fjoralba Zeka,Jo Vandesompele +83 more
TL;DR: Two surveys of over 1,700 publications whose authors use quantitative real-time PCR (qPCR) reveal a lack of transparent and comprehensive reporting of essential technical information.
Journal ArticleDOI
Bromodomain Protein BRD4 Is a Transcriptional Repressor of Autophagy and Lysosomal Function.
Jun-ichi Sakamaki,Simon Wilkinson,Marcel Hahn,Nilgun Tasdemir,Jim O'Prey,William Clark,Ann Hedley,Colin Nixon,Jaclyn S. Long,Maria New,Tim Van Acker,Sharon A. Tooze,Scott W. Lowe,Scott W. Lowe,Ivan Dikic,Ivan Dikic,Kevin M. Ryan +16 more
TL;DR: It is reported that the epigenetic reader BRD4 and the methyltransferase G9a repress a TFEB/TFE3/MITF-independent transcriptional program that promotes autophagy and lysosome biogenesis, and is directed independently and also reciprocally to the growth-promoting properties ofBRD4.
Journal ArticleDOI
The Small GTPase Arf6: An Overview of Its Mechanisms of Action and of Its Role in Host⁻Pathogen Interactions and Innate Immunity.
TL;DR: The small GTase Arf6 has several important functions in intracellular vesicular trafficking and regulates the recycling of different types of cargo internalized via clathrin-dependent or -independent endocytosis and its role in innate immunity and host–pathogen interactions is reviewed.
Journal ArticleDOI
Reconstructing the TIR side of the myddosome: a paradigm for TIR-TIR interactions
Laurens Vyncke,Celia Bovijn,Ewald Pauwels,Tim Van Acker,Elien Ruyssinck,Elianne Burg,Jan Tavernier,Frank Peelman +7 more
TL;DR: In this paper, the authors combine the mammalian two-hybrid system MAPPIT and saturation mutagenesis to complement and extend crystallographic and nuclear magnetic resonance data, and reveal how TIR domains interact.
Reconstructing the TIR side of the Myddosome: a paradigm for TIR-TIR interactions?
Laurens Vyncke,Celia Bovijn,Ewald Pauwels,Tim Van Acker,Elien Ruyssinck,Jan Tavernier,Frank Peelman +6 more
TL;DR: The mammalian two-hybrid system MAPPIT and saturation mutagenesis is combined to complement and extend crystallographic and nuclear magnetic resonance data, and how TIR domains interact is revealed, providing a paradigm for the interaction of mammalian T IR domains.