O
Ole Paulsen
Researcher at University of Cambridge
Publications - 147
Citations - 14496
Ole Paulsen is an academic researcher from University of Cambridge. The author has contributed to research in topics: Long-term potentiation & Synaptic plasticity. The author has an hindex of 60, co-authored 142 publications receiving 12881 citations. Previous affiliations of Ole Paulsen include University of Oslo & Norwegian University of Science and Technology.
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Journal ArticleDOI
Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons
TL;DR: It is demonstrated that individual GABAergic interneurons can effectively phase spontaneous firing and subthreshold oscillations in hippocampal pyramidal cells at 4–7 Hz, and this GABAergic mechanism is sufficient to synchronize the firing of pyramsidal cells.
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Cholinergic induction of network oscillations at 40 Hz in the hippocampus in vitro
TL;DR: In this paper, it was shown that cholinergic activation is sufficient to induce 40-Hz network oscillations in the hippocampus in vitro, which can persist for hours in the CA3 subfield.
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Importance of the Intracellular Domain of NR2 Subunits for NMDA Receptor Function In Vivo
Rolf Sprengel,Bettina Suchanek,Carla Amico,Rossella Brusa,Nail Burnashev,Andrei Rozov,OØivind Hvalby,Vidar Jensen,Ole Paulsen,Per Andersen,Jeansok J. Kim,Richard F. Thompson,William Sun,Lorna C. Webster,Seth G. N. Grant,Jens Eilers,Arthur Konnerth,Jianying Li,James O. McNamara,Peter H. Seeburg +19 more
TL;DR: It is shown that gene-targeted mice expressing NMDA receptors without the large intracellular C-terminal domain of any one of three NR2 subunits phenotypically resemble mice made deficient in that particular subunit.
Journal Article
Effects of ketamine on sensory perception: evidence for a role of N-methyl-D-aspartate receptors.
Ivar Øye,Ole Paulsen,A Maurset +2 more
TL;DR: In healthy volunteers, the most obvious effect of subanesthetic doses of both enantiomers was altered sensory perception, and (S)-Ketamine was 4 times as potent as (R)-ketamine in reducing pain perception and in causing auditory and visual disturbances.
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Role of GABAergic inhibition in hippocampal network oscillations.
Edward O. Mann,Ole Paulsen +1 more
TL;DR: The mechanisms by which synaptic inhibition can control the precise timing of spike generation are reviewed, by way of effects of GABAergic events on membrane conductance ('shunting' inhibition) and membrane potential ('hyperpolarizing' inhibition).