O
Oula Penate-Medina
Researcher at University of Kiel
Publications - 18
Citations - 1857
Oula Penate-Medina is an academic researcher from University of Kiel. The author has contributed to research in topics: In vivo & Drug delivery. The author has an hindex of 8, co-authored 18 publications receiving 1584 citations. Previous affiliations of Oula Penate-Medina include Kettering University & Memorial Sloan Kettering Cancer Center.
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Journal ArticleDOI
Multimodal silica nanoparticles are effective cancer-targeted probes in a model of human melanoma
Miriam Benezra,Oula Penate-Medina,Pat Zanzonico,David Schaer,Hooisweng Ow,Andrew Burns,Elisa DeStanchina,Valerie A. Longo,Erik Herz,Srikant K. Iyer,Jedd D. Wolchok,Steven M. Larson,Ulrich Wiesner,Michelle S. Bradbury +13 more
TL;DR: The sensitive, real-time detection and imaging of lymphatic drainage patterns, particle clearance rates, nodal metastases, and differential tumor burden in a large-animal model of melanoma highlighted the distinct potential advantage of this multimodal platform for staging metastatic disease in the clinical setting.
Journal ArticleDOI
Clinical translation of an ultrasmall inorganic optical-PET imaging nanoparticle probe
Evan H. Phillips,Oula Penate-Medina,Pat Zanzonico,Richard D. Carvajal,Pauliah Mohan,Yunpeng Ye,John L. Humm,Mithat Gonen,Hovanes Kalaigian,Heiko Schöder,H. William Strauss,Steven M. Larson,Ulrich Wiesner,Michelle S. Bradbury +13 more
TL;DR: The authors found that the nanoparticles were not toxic in a small group of five patients with metastatic melanoma and that the particles were excreted intact via the kidneys and bladder, suggesting safe use of these particles in human cancer diagnostics.
Journal ArticleDOI
Fluorescent Silica Nanoparticles with Efficient Urinary Excretion for Nanomedicine
Andrew Burns,Jelena Vider,Hooisweng Ow,Erik Herz,Oula Penate-Medina,Martin Baumgart,Steven M. Larson,Ulrich Wiesner,Michelle S. Bradbury +8 more
TL;DR: A new generation of near-infrared fluorescent core-shell silica-based nanoparticles (C dots) tuned to hydrodynamic diameters of 3.3 and 6.0 nm with improved photophysical characteristics over the parent dye are created, suggesting a promising clinically translatable materials platform which may be adapted for tumor targeting and treatment.
Journal ArticleDOI
Liposomes and inorganic nanoparticles for drug delivery and cancer imaging.
TL;DR: Different strategies for targeted delivery, imaging and controlled release are described, and the ability of small inorganic particles as well as larger nanoparticles to be used broadly in human diagnostics and drug delivery is discussed.
Journal ArticleDOI
X-ray-Based Techniques to Study the Nano-Bio Interface
Carlos Sanchez-Cano,Ramon A. Alvarez-Puebla,John M. Abendroth,Tobias Beck,Robert H. Blick,Yuan Cao,Frank Caruso,Indranath Chakraborty,Henry N. Chapman,Chunying Chen,Bruce E. Cohen,Andre L.C. Conceição,David P. Cormode,Daxiang Cui,Kenneth A. Dawson,Gerald Falkenberg,Chunhai Fan,Neus Feliu,Mingyuan Gao,E. Gargioni,Claus C. Glüer,Florian Grüner,Moustapha Hassan,Yong Hu,Yalan Huang,Samuel Huber,Nils Huse,Yanan Kang,Ali Khademhosseini,Thomas F. Keller,Christian Körnig,Nicholas A. Kotov,Dorota Koziej,Xing-Jie Liang,Beibei Liu,Sijin Liu,Yang Liu,Ziyao Liu,Luis M. Liz-Marzán,Xiaowei Ma,Andres Machicote,Wolfgang Maison,Adrian P. Mancuso,Adrian P. Mancuso,Saad Megahed,Bert Nickel,Ferdinand Otto,Cristina Palencia,Sakura Pascarelli,Arwen R. Pearson,Oula Penate-Medina,Bing Qi,Joachim O. Rädler,Joseph J. Richardson,Axel Rosenhahn,Kai Rothkamm,Michael Rübhausen,Milan K. Sanyal,Raymond E. Schaak,Heinz Peter Schlemmer,Marius Schmidt,Oliver Schmutzler,Theo Schotten,Florian Schulz,A. K. Sood,Kathryn Spiers,Theresa Staufer,Dominik M. Stemer,Andreas Stierle,Xing Sun,Xing Sun,Gohar Tsakanova,Paul S. Weiss,Horst Weller,Fabian Westermeier,Ming Xu,Huijie Yan,Yuan Zeng,Ying Zhao,Yuliang Zhao,Dingcheng Zhu,Ying Zhu,Wolfgang J. Parak,Wolfgang J. Parak +83 more
TL;DR: X-ray-based analytics are routinely applied in many fields, including physics, chemistry, materials science, and engineering as discussed by the authors, but the full potential of such techniques in the life sciences and medicine has not yet been fully exploited.