P
Pál Gergely
Researcher at University of Debrecen
Publications - 200
Citations - 6031
Pál Gergely is an academic researcher from University of Debrecen. The author has contributed to research in topics: Glycogen phosphorylase & Phosphorylase kinase. The author has an hindex of 42, co-authored 199 publications receiving 5643 citations. Previous affiliations of Pál Gergely include Hungarian Academy of Sciences & Novartis.
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Peroxynitrite-induced cytotoxicity: mechanism and opportunities for intervention
TL;DR: The cytotoxic effects (apoptosis and necrosis) of peroxynitrite are reviewed focusing on the role of accelerated ADP-ribose turnover and regulatory mechanisms of per oxynitrites-induced cytotoxicity such as antioxidant status, calcium signalling, NFkappaB activation, protein phosphorylation, cellular adaptation are discussed.
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The selective sphingosine 1-phosphate receptor modulator BAF312 redirects lymphocyte distribution and has species-specific effects on heart rate.
Pál Gergely,Barbara Nuesslein-Hildesheim,Danilo Guerini,Volker Brinkmann,Martin Traebert,Christian Bruns,Shifeng Pan,Nathanael S. Gray,Klaus Hinterding,Nigel Graham Cooke,Andrea Groenewegen,A Vitaliti,Tobias Sing,O Luttringer,J Yang,Anne Gardin,N Wang,W J Crumb,M Saltzman,Mara Rosenberg,E Wallström +20 more
TL;DR: The immunomodulatory potential of BAF312 and the S1P receptor‐mediated effects on heart rate are characterized using preclinical and human data.
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PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Péter Bai,Péter Bai,Carles Cantó,Attila Brunyanszki,Aline Huber,Magdolna Szántó,Yana Cen,Hiroyasu Yamamoto,Sander M. Houten,Borbála Kiss,Borbála Kiss,Hugues Oudart,Pál Gergely,Josiane Ménissier-de Murcia,Valérie Schreiber,Anthony A. Sauve,Johan Auwerx +16 more
TL;DR: The results indicate that PARP-2 deficiency increases SIRT1 activity in cultured myotubes, however, this increase was not due to changes in NAD(+) levels, but to an increase in SIRT 1 expression, as PARp-2 acts as a direct negative regulator of the SIRT2 promoter.
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A2A adenosine receptors and C/EBPβ are crucially required for IL-10 production by macrophages exposed to Escherichia coli
Balázs Csóka,Zoltán Németh,László Virág,Pál Gergely,S. Joseph Leibovich,Pal Pacher,Chun Xiao Sun,Michael R. Blackburn,E. Sylvester Vizi,Edwin A. Deitch,György Haskó,György Haskó +11 more
TL;DR: The results suggest that the A(2A) receptor-C/EBPbeta axis is critical for IL-10 production after bacterial infection, and that TRAF6 impairs the potentiating effect of adenosine.
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Glucose Analog Inhibitors of Glycogen Phosphorylases as Potential Antidiabetic Agents: Recent Developments
TL;DR: Recent developments in the synthesis and evaluation of glucopyranosylidene-spiro-thiohydantoin 18 and further anomerically bifunctional glucose derivatives which may be good inhibitors of GP are surveyed.