Treg cells expressing the coinhibitory molecule TIGIT selectively inhibit proinflammatory Th1 and Th17 cell responses.
Nicole Joller,Ester Lozano,Patrick R. Burkett,Bonny Patel,Sheng Xiao,Chen Zhu,Junrong Xia,Tze Guan Tan,Esen Sefik,Vijay Yajnik,Arlene H. Sharpe,Arlene H. Sharpe,Francisco J. Quintana,Diane Mathis,Christophe Benoist,David A. Hafler,Vijay K. Kuchroo +16 more
TLDR
TIGIT expression identifies a Treg cell subset that demonstrates selectivity for suppression of Th1 and Th17 cell but not Th2 cell responses.About:
This article is published in Immunity.The article was published on 2014-04-17 and is currently open access. It has received 636 citations till now. The article focuses on the topics: TIGIT & FOXP3.read more
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Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation
TL;DR: Co-inhibitory receptors, such as CTLA-4 and PD-1, have an important role in regulating T cell responses and have proven to be effective targets in the setting of chronic diseases where constitutive co- inhibitory receptor expression on T cells dampens effector T-cell responses.
Journal ArticleDOI
The immunology of asthma
Bart N. Lambrecht,Hamida Hammad +1 more
TL;DR: Results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans are discussed and the extraordinary heterogeneity of asthma is described.
Journal ArticleDOI
Single-Cell Map of Diverse Immune Phenotypes in the Breast Tumor Microenvironment.
Elham Azizi,Ambrose J. Carr,Ambrose J. Carr,George Plitas,Andrew E. Cornish,Catherine Konopacki,Sandhya Prabhakaran,Juozas Nainys,Juozas Nainys,Kenmin Wu,Vaidotas Kiseliovas,Vaidotas Kiseliovas,Manu Setty,Kristy Choi,Rachel M. Fromme,Phuong Dao,Peter T. McKenney,Peter T. McKenney,Ruby C. Wasti,Krishna Kadaveru,Linas Mazutis,Alexander Y. Rudensky,Dana Pe'er +22 more
TL;DR: A preprocessing pipeline, SEQC, and a Bayesian clustering and normalization method, Biscuit, are developed to address computational challenges inherent to single-cell data and support a model of continuous activation in T cells and do not comport with the macrophage polarization model in cancer.
Journal ArticleDOI
Coinhibitory Pathways in Immunotherapy for Cancer.
TL;DR: The immunoregulatory functions of coinhibitory pathways and their translation to effective immunotherapies for cancer are discussed and blockade of the PD-1 and CTLA-4 checkpoints is proving to be an effective and durable cancer immunotherapy in a subset of patients.
Journal ArticleDOI
Gut bacteria from multiple sclerosis patients modulate human T cells and exacerbate symptoms in mouse models.
Egle Cekanaviciute,Bryan B. Yoo,Tessel F. Runia,Justine W. Debelius,Sneha Singh,Charlotte A. Nelson,Rachel Kanner,Yadira Bencosme,Yun Kyung Lee,Stephen L. Hauser,Elizabeth Crabtree-Hartman,Ilana Katz Sand,Mar Gacias,Yungjiao Zhu,Patrizia Casaccia,Patrizia Casaccia,Bruce A.C. Cree,Rob Knight,Sarkis K. Mazmanian,Sergio E. Baranzini +19 more
TL;DR: The results expand the knowledge of the microbial regulation of immunity and may provide a basis for the development of microbiome-based therapeutics in autoimmune diseases.
References
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Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells.
Estelle Bettelli,Yijun Carrier,Wenda Gao,Thomas Korn,Terry B. Strom,Mohamed Oukka,Howard L. Weiner,Vijay K. Kuchroo +7 more
TL;DR: It is shown that IL-6, an acute phase protein induced during inflammation, completely inhibits the generation of Foxp3+ Treg cells induced by TGF-β, and the data demonstrate a dichotomy in thegeneration of pathogenic (TH17) T cells that induce autoimmunity and regulatory (Foxp3+) T Cells that inhibit autoimmune tissue injury.
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Interleukin-10-deficient mice develop chronic enterocolitis
TL;DR: The results indicate that the bowel inflammation in the mutants originates from uncontrolled immune responses stimulated by enteric antigens and that IL-10 is an essential immunoregulator in the intestinal tract.
Journal ArticleDOI
CD4+CD25+ Immunoregulatory T Cells Suppress Polyclonal T Cell Activation In Vitro by Inhibiting Interleukin 2 Production
TL;DR: Data support the concept that the CD4+CD25+ T cells in normal mice may represent a distinct lineage of “professional” suppressor cells.
Journal ArticleDOI
CTLA-4 Control over Foxp3+ Regulatory T Cell Function
Kajsa Wing,Yasushi Onishi,Yasushi Onishi,Paz Prieto-Martin,Tomoyuki Yamaguchi,Makoto Miyara,Zoltan Fehervari,Takashi Nomura,Shimon Sakaguchi,Shimon Sakaguchi +9 more
TL;DR: It is shown that a specific deficiency of cytotoxic T lymphocyte antigen 4 (CTLA-4) in Tregs results in spontaneous development of systemic lymphoproliferation, fatal T cell–mediated autoimmune disease, and hyperproduction of immunoglobulin E in mice.
Journal ArticleDOI
Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse.
Mary E. Brunkow,Jeffery Ew,Hjerrild Ka,Bryan W. Paeper,L B Clark,Yasayko Sa,John E. Wilkinson,David J. Galas,Steven F. Ziegler,Fred Ramsdell +9 more
TL;DR: Genetic complementation demonstrates that the protein product of Foxp3, scurfin, is essential for normal immune homeostasis.