P
Paul G. Richardson
Researcher at Harvard University
Publications - 1631
Citations - 174221
Paul G. Richardson is an academic researcher from Harvard University. The author has contributed to research in topics: Multiple myeloma & Bortezomib. The author has an hindex of 183, co-authored 1533 publications receiving 155912 citations. Previous affiliations of Paul G. Richardson include Broomfield Hospital & Dartmouth College.
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Journal ArticleDOI
Preliminary safety and efficacy of TH-302, an investigational hypoxia-targeted drug, and dexamethasone (dex) in patients (pts) with relapsed/refractory multiple myeloma (RR MM).
Jacob P. Laubach,Noopur Raje,Philippe Armand,Robert L. Schlossman,Jacalyn Rosenblatt,Jeffrey Matous,J. A. Hedlund,Michael Gary Martin,Craig H. Reynolds,Kenneth H. Shain,Ira Zackon,Laura Stampleman,Erica N Boswell,Stacey Chuma,Rebecca Liguori,Damian Handisides,Stew Kroll,Kenneth C. Anderson,Paul G. Richardson,Irene M. Ghobrial +19 more
TL;DR: In the dose-escalation stage of the study, the maximum tolerated dose (MTD) of biweekly TH-302 was established at 340 mg/m2 and preliminary activity was reported based on the modified IMWG guidelines (Ghobrial et al., ASH 2013).
Journal Article
Pharmacodynamic profiling defines the significant biological activities of the novel proteasome inhibitor NPI-0052: Comparison with Velcade® (Bortezomib)
Ta-Hsiang Chao,Dharminder Chauhan,Gordafaried Deyanat-Yazdi,Laurence Catley,Paul G. Richardson,G. Kenneth Lloyd,Neuteboom Saskia Theodora Corn,Kenneth C. Anderson,Michael A. Palladino +8 more
TL;DR: Different pharmacodynamic profiles for NPI-0052 and Velcade® are demonstrated and support the clinical use of NPI -0052 on a weekly regimen, which resulted in significant inhibition of tumor growth and prolonged survival.
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The Role of B Cell-Activating Factor (BAFF) in the Biology of Multiple Myeloma (MM).
Noopur Raje,Shaji Kumar,Teru Hideshima,Kenji Ishitsuka,Hiroshi Yasui,Yu-Tzu Tai,Norihiko Shiraishi,Tanyel Kizeltepe,Shweta Chhetri,Sonia Vallet,Robert L. Schlossman,Paul G. Richardson,Nikhil C. Munshi,Kenneth C. Anderson +13 more
TL;DR: In this article, the authors performed gene expression profiling (GEP) on CD 138+ plasma cells isolated from 90 MM patients (45 newly diagnosed and 45 relapsed) and 11 healthy controls using the Affymetrix U133A arrays.
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Bcl6 as a Novel Therapeutic Target in Multiple Myeloma (MM).
Teru Hideshima,Constantine S. Mitsiades,Hiroshi Ikeda,Dharminder Chauhan,Noopur Raje,Gullu Gorgun,Mariateresa Fulciniti,Diana Cirstea,Giulia Perron,Loredana Santo,Ayaka Hideshima,Klaus Podar,Nikhil C. Munshi,Paul G. Richardson,Daniel R. Carrasco,Kenneth C. Anderson +15 more
TL;DR: Modulation of Bcl6 expression and its sequelae in human MM cells in the context of bone marrow (BM) microenvironment is examined to suggest that Bcl-6 expression is modulated via both JAk/STAT3 signaling and gp130 family member cytokines.
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PWE-157 Early Tips (transjugular Intrahepatic Portosystemic Shunt) For Acute Variceal Bleeding Complicating Alcoholic Hepatitis (ah)
TL;DR: In patients with variceal bleeding complicating AH there is a higher 30 day and 6 month mortality in patients managed with a primary TIPS in comparison to patients with cirrhosis.