Paul G. Richardson

TL;DR: It is demonstrated that tubacin combined with bortezomib mediates significant anti-MM activity, providing the framework for clinical evaluation of combined therapy to improve patient outcome in MM.

TL;DR: The importance of stromal–MM cell interactions in regulating VEGF and IL-6 secretion is demonstrated, and additional mechanisms whereby thalidomide and IMiD1-CC4047 act against MM cells in the BM millieu are suggested.

TL;DR: Bortezomib-associated peripheral neuropathy seemed reversible in the majority of patients after dose reduction or discontinuation, and the overall occurrence was independent of baseline neuropathy or type of prior therapy.

TL;DR: Analysis of fosmid sequences derived from the uncultivated marine crenarchaeote, Cenarchaeum symbiosum, focused on the reconstruction of carbon and energy metabolism substantiate the likely global metabolic importance of Cren archaeal importance with respect to key steps in the biogeochemical transformation ofcarbon and nitrogen in marine ecosystems.

TL;DR: It is shown by complete genome sequencing of two symbiotic, photosynthetic, Bradyrhizobium strains, BTAi1 and ORS278, that canonical nodABC genes and typical lipochito-oligosaccharidic Nod factors are not required for symbiosis in some legumes.