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Paul G. Richardson
Researcher at Harvard University
Publications - 1631
Citations - 174221
Paul G. Richardson is an academic researcher from Harvard University. The author has contributed to research in topics: Multiple myeloma & Bortezomib. The author has an hindex of 183, co-authored 1533 publications receiving 155912 citations. Previous affiliations of Paul G. Richardson include Broomfield Hospital & Dartmouth College.
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Journal ArticleDOI
Bortezomib appears to overcome the poor prognosis conferred by chromosome 13 deletion in phase 2 and 3 trials
Sundar Jagannath,Paul G. Richardson,Pieter Sonneveld,Michael W. Schuster,David Irwin,Edward A. Stadtmauer,Thierry Facon,Jean-Luc Harousseau,J. M. Cowan,Kenneth C. Anderson +9 more
TL;DR: Matched-pairs analyses suggest that bortezomib may overcome some of the poor impact of del(13) as an independent prognostic factor, however, sample sizes were very small; these findings require confirmation from further studies.
Journal ArticleDOI
The validity of viral hepatitis and chronic liver disease diagnoses in Veterans Affairs administrative databases
Jennifer R. Kramer,Jennifer R. Kramer,Jessica A. Davila,Jessica A. Davila,E. D. Miller,Paul G. Richardson,Paul G. Richardson,Thomas P. Giordano,Thomas P. Giordano,Hashem B. El-Serag,Hashem B. El-Serag +10 more
TL;DR: This work has shown that liver disease codes for liver disease have not been determined by the International Classification of Diseases‐9, and the validity of these codes is still not determined.
Journal ArticleDOI
Single-Agent Bortezomib in Previously Untreated Multiple Myeloma: Efficacy, Characterization of Peripheral Neuropathy, and Molecular Correlations With Response and Neuropathy
Paul G. Richardson,Wanling Xie,Constantine S. Mitsiades,Asher Chanan-Khan,Sagar Lonial,Hani Hassoun,David Avigan,Anne Louise Oaklander,David J. Kuter,Patrick Y. Wen,Santosh Kesari,Hannah R. Briemberg,Robert L. Schlossman,Nikhil C. Munshi,L. Thompson Heffner,Deborah Doss,Dixie Lee Esseltine,Edie Weller,Kenneth C. Anderson,Anthony A. Amato +19 more
TL;DR: Baseline myeloma-associated neuropathy seems more common than previously reported, and bortezomib- associated neuropathy, although a common toxicity, is reversible in most patients.
Journal ArticleDOI
CRM1 inhibition induces tumor cell cytotoxicity and impairs osteoclastogenesis in multiple myeloma: molecular mechanisms and therapeutic implications.
Yu-Tzu Tai,Yosef Landesman,Chirag Acharya,Yolanda Calle,Mike Y Zhong,Michele Cea,Daniel Tannenbaum,Antonia Cagnetta,Michaela R. Reagan,Aditya Munshi,William Senapedis,Jean-Richard Saint-Martin,Trinayan Kashyap,Sharon Shacham,M. Kauffman,Yumei Gu,Lizi Wu,Irene M. Ghobrial,Fenghuang Zhan,Andrew L. Kung,S. A. Schey,Paul G. Richardson,Nikhil C. Munshi,Kenneth C. Anderson +23 more
TL;DR: It is shown that chromosome region maintenance 1 (CRM1) is highly expressed in patients with MM, plasma cell leukemia cells and increased in patient cells resistant to bortezomib treatment, which support clinical development of SINE CRM1 antagonists to improve patient outcome in MM.
Journal ArticleDOI
Mechanisms of Thermal Adaptation Revealed From the Genomes of the Antarctic Archaea Methanogenium frigidum and Methanococcoides burtonii
Neil F. W. Saunders,Torsten Thomas,Paul M. G. Curmi,John S. Mattick,Elizabeth Kuczek,Rob Slade,John Davis,Peter D. Franzmann,David Boone,Karl Rusterholtz,Robert A. Feldman,Chris Gates,Shellie R. Bench,Kevin R. Sowers,Kristen Kadner,Andrea Aerts,Paramvir S. Dehal,Chris Detter,Tijana Glavina,Susan Lucas,Paul G. Richardson,Frank W. Larimer,Loren Hauser,Miriam Land,Ricardo Cavicchioli +24 more
TL;DR: Comparative genomics revealed trends in amino acid and tRNA composition, and structural features of proteins from cold-adapted Archaea, and indicated that GC content is the major factor influencing tRNA stability in hyperthermophiles, but not in the psychrophiles, mesophiles or moderate thermophiles