P
Paul G. Richardson
Researcher at Harvard University
Publications - 1631
Citations - 174221
Paul G. Richardson is an academic researcher from Harvard University. The author has contributed to research in topics: Multiple myeloma & Bortezomib. The author has an hindex of 183, co-authored 1533 publications receiving 155912 citations. Previous affiliations of Paul G. Richardson include Broomfield Hospital & Dartmouth College.
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Journal ArticleDOI
Bortezomib plus melphalan and prednisone for initial treatment of multiple myeloma.
Jesús F. San Miguel,Rudolf Schlag,Nuriet K. Khuageva,Meletios A. Dimopoulos,Ofer Shpilberg,Martin Kropff,Ivan Spicka,Maria Teresa Petrucci,Antonio Palumbo,Olga Samoilova,Anna Dmoszynska,Kudrat Abdulkadyrov,Rik Schots,Bin Jiang,Maria-Victoria Mateos,Kenneth C. Anderson,Dixie Lee Esseltine,Kevin Liu,Andrew Cakana,Helgi van de Velde,Paul G. Richardson +20 more
TL;DR: Bortezomib plus melphalan-prednisone alone in patients with newly diagnosed myeloma who were ineligible for high-dose therapy was superior to melphAlan-predisonsone alone.
Journal ArticleDOI
International Myeloma Working Group consensus criteria for response and minimal residual disease assessment in multiple myeloma
Shaji Kumar,Bruno Paiva,Kenneth C. Anderson,Brian G.M. Durie,Ola Landgren,Philippe Moreau,Nikhil C. Munshi,Sagar Lonial,Joan Bladé,Maria-Victoria Mateos,Meletios A. Dimopoulos,Efstathios Kastritis,Mario Boccadoro,Mario Boccadoro,Robert Z. Orlowski,Hartmut Goldschmidt,Andrew Spencer,Jian Hou,Wee Joo Chng,Saad Z. Usmani,Elena Zamagni,Kazuyuki Shimizu,Sundar Jagannath,Hans Erik Johnsen,Evangelos Terpos,Anthony Reiman,Robert A. Kyle,Pieter Sonneveld,Paul G. Richardson,Philip L. McCarthy,Heinz Ludwig,Wenming Chen,Michele Cavo,Jean Luc Harousseau,Suzanne Lentzsch,Jens Hillengass,Antonio Palumbo,Alberto Orfao,S. Vincent Rajkumar,Jesús F. San Miguel,Hervé Avet-Loiseau +40 more
TL;DR: Several aspects of disease response assessment are clarified, along with endpoints for clinical trials, and future directions for disease response assessments are highlighted, to allow uniform reporting within and outside clinical trials.
Journal ArticleDOI
The draft genome of Ciona intestinalis : insights into chordate and vertebrate origins
Paramvir S. Dehal,Yutaka Satou,Robert K. Campbell,Jarrod Chapman,Bernard M. Degnan,Anthony W. De Tomaso,Brad Davidson,Anna Di Gregorio,Maarten D. Sollewijn Gelpke,David Goodstein,Naoe Harafuji,Kenneth E. M. Hastings,Isaac Ho,Kohji Hotta,Wayne Huang,Takeshi Kawashima,Patrick Lemaire,Diego Martinez,Ian A. Meinertzhagen,Simona Necula,Masaru Nonaka,Nik Putnam,Sam Rash,Hidetoshi Saiga,Masanobu Satake,Astrid Terry,Lixy Yamada,Hong Gang Wang,Satoko Awazu,Kaoru Azumi,Jeffrey L. Boore,Margherita Branno,Stephen T. Chin-Bow,Rosaria DeSantis,Sharon A. Doyle,Pilar Francino,David N. Keys,David N. Keys,Shinobu Haga,Hiroko Hayashi,Kyosuke Hino,Kaoru S. Imai,Kazuo Inaba,Shungo Kano,Shungo Kano,Kenji Kobayashi,Mari Kobayashi,Byung In Lee,Kazuhiro W. Makabe,Chitra Manohar,Giorgio Matassi,Mónica Medina,Yasuaki Mochizuki,Steve Mount,Tomomi Morishita,Sachiko Miura,Akie Nakayama,Satoko Nishizaka,Hisayo Nomoto,Fumiko Ohta,Kazuko Oishi,Isidore Rigoutsos,Masako Sano,Akane Sasaki,Yasunori Sasakura,Eiichi Shoguchi,Tadasu Shin-I,Antoinetta Spagnuolo,Didier Y.R. Stainier,Miho Suzuki,Olivier Tassy,Naohito Takatori,Miki Tokuoka,Kasumi Yagi,Fumiko Yoshizaki,Shuichi Wada,Cindy Zhang,P. Douglas Hyatt,Frank W. Larimer,Chris Detter,Norman A. Doggett,Tijana Glavina,Trevor Hawkins,Paul G. Richardson,Susan Lucas,Yuji Kohara,Michael Levine,Nori Satoh,Daniel S. Rokhsar,Daniel S. Rokhsar +89 more
TL;DR: A draft of the protein-coding portion of the genome of the most studied ascidian, Ciona intestinalis, is generated, suggesting that ascidians contain the basic ancestral complement of genes involved in cell signaling and development.
Journal Article
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells.
Teru Hideshima,Paul G. Richardson,Dharminder Chauhan,Vito J. Palombella,Peter J. Elliott,Julian Adams,Kenneth C. Anderson +6 more
TL;DR: It is demonstrated that the proteasome inhibitor PS-341 both acts directly on MM cells and alters cellular interactions and cytokine secretion in the BM millieu to inhibit tumor cell growth, induce apoptosis, and overcome drug resistance.
Journal ArticleDOI
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34
Marjon van Slegtenhorst,Ronald de Hoogt,C Hermans,Mark Nellist,Bart Janssen,Senno Verhoef,Dick Lindhout,Ans M.W. van den Ouweland,Dicky J. J. Halley,Janet M. Young,M. W. Burley,S. Jeremiah,Karen J. Woodward,Joseph Nahmias,Margaret Fox,Rosemary Ekong,John D. Osborne,Jonathan Wolfe,Sue Povey,Russell G. Snell,Jeremy Peter Cheadle,Alistair C. Jones,Maria Tachataki,David Ravine,Julian R. Sampson,Mary Pat Reeve,Paul G. Richardson,Friederike Wilmer,Cheryl Munro,Trevor Hawkins,T. Sepp,Johari Mohd Ali,Susannah Ward,Andrew Green,John R. Yates,J. Kwiatkowska,Elizabeth P. Henske,M. Priscilla Short,J Haines,Sergiusz Jozwiak,David J. Kwiatkowski +40 more
TL;DR: Thirty-two distinct mutations were identified in TSC1, 30 of which were truncating, and a single mutation was seen in six apparently unrelated patients, which suggests that hamartin acts as a tumor suppressor.