P
Paul G. Richardson
Researcher at Harvard University
Publications - 1631
Citations - 174221
Paul G. Richardson is an academic researcher from Harvard University. The author has contributed to research in topics: Multiple myeloma & Bortezomib. The author has an hindex of 183, co-authored 1533 publications receiving 155912 citations. Previous affiliations of Paul G. Richardson include Broomfield Hospital & Dartmouth College.
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Journal ArticleDOI
Systematic review of defibrotide studies in the treatment of veno-occlusive disease/sinusoidal obstruction syndrome (VOD/SOS).
TL;DR: This analysis provides the largest assessment of survival in patients treated with defibrotide for VOD/SOS with or without MOD, and shows survival was 41% and 70%, respectively, for the population of patients receiving any dose of defib rotide.
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Differential and Limited Expression of Mutant Alleles in Multiple Myeloma
Naim U. Rashid,Adam S. Sperling,Niccolo Bolli,Niccolo Bolli,David C. Wedge,Peter Van Loo,Peter Van Loo,Yu-Tzu Tai,Masood A. Shammas,Masood A. Shammas,Mariateresa Fulciniti,Mehmet Kemal Samur,Paul G. Richardson,Florence Magrangeas,Stephane Minvielle,P. Andrew Futreal,Kenneth C. Anderson,Hervé Avet-Loiseau,Peter J. Campbell,Peter J. Campbell,Giovanni Parmigiani,Nikhil C. Munshi,Nikhil C. Munshi +22 more
TL;DR: It is found that the majority of previously identified mutations occur within genes with very low or no detectable expression, and among mutated genes that are expressed, there often is allele-specific expression where either the mutant or wild-type allele is suppressed.
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Immunomodulatory drug lenalidomide (CC-5013, IMiD3) augments anti-CD40 SGN-40-induced cytotoxicity in human multiple myeloma: Clinical implications.
Yu-Tzu Tai,Laurence Catley,Xian-Feng Li,Rory Coffey,Iris Breitkreutz,Jooeun Bae,Klaus Podar,Teru Hideshima,Dharminder Chauhan,Robert L. Schlossman,Paul G. Richardson,Steven P. Treon,Iqbal S. Grewal,Nikhil C. Munshi,Kenneth C. Anderson +14 more
TL;DR: It is demonstrated that the addition of lenalidomide to SGN-40 enhances cytotoxicity against MM cells, providing the framework for combined lenalidumide and SGN -40 in a new treatment paradigm to both target MM cells directly and induce immune effectors against MM.
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Development of a conceptual model to illustrate the impact of multiple myeloma and its treatment on health-related quality of life
Rachid Baz,H. M. Lin,Ai-Min Hui,R. D. Harvey,Kathleen Colson,Katy Gallop,P. Swinburn,Jacob P. Laubach,Deborah Berg,Paul G. Richardson +9 more
TL;DR: The conceptual model developed in this study illustrates the many aspects of multiple myeloma and its treatment and how they can have a negative impact on patients’ HRQL.
Journal ArticleDOI
Exercise training improves cutaneous microvascular function in nonalcoholic fatty liver disease.
Christopher J. A. Pugh,Daniel J. Cuthbertson,Victoria S. Sprung,Graham J. Kemp,Paul G. Richardson,A. Margot Umpleby,Daniel J. Green,Daniel J. Green,N. Timothy Cable,Helen Jones +9 more
TL;DR: The benefit of exercise training compared with conventional care strongly supports a role for exercise in the prevention of CVD in NAFLD.