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Paul S. Donnelly
Researcher at University of Melbourne
Publications - 215
Citations - 7933
Paul S. Donnelly is an academic researcher from University of Melbourne. The author has contributed to research in topics: Copper & Biodistribution. The author has an hindex of 45, co-authored 202 publications receiving 6785 citations. Previous affiliations of Paul S. Donnelly include University of Western Australia & University of Cambridge.
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Journal ArticleDOI
Copper complexes of bis(thiosemicarbazones): from chemotherapeutics to diagnostic and therapeutic radiopharmaceuticals
TL;DR: This critical review presents an historical perspective of Cu(II) complexes progression from potential chemotherapeutics through to more recent applications in nuclear medicine and more recent investigations into their potential as therapeutics for Alzheimer's disease.
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Increasing Cu bioavailability inhibits Aβ oligomers and tau phosphorylation
Peter J. Crouch,Lin Wai Hung,Paul A. Adlard,Mikhalina Cortes,Varsha Lal,Gulay Filiz,Keyla Perez,Milawaty Nurjono,Aphrodite Caragounis,Tai Du,Katrina M. Laughton,Irene Volitakis,Ashley I. Bush,Qiao-Xin Li,Colin L. Masters,Roberto Cappai,Robert A. Cherny,Paul S. Donnelly,Anthony R. White,Kevin J. Barnham +19 more
TL;DR: It is demonstrated that increasing intracellular copper bioavailability can restore cognitive function by inhibiting the accumulation of neurotoxic Aβ trimers and phosphorylated tau.
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Comparison of (64)Cu-complexing bifunctional chelators for radioimmunoconjugation: labeling efficiency, specific activity, and in vitro/in vivo stability.
Maggie S. Cooper,Michelle T. Ma,Kavitha Sunassee,Karen P. Shaw,Jennifer D Williams,Rowena L. Paul,Paul S. Donnelly,Philip J. Blower +7 more
TL;DR: While all the macrocyclic bifunctional chelators are suitable for molecular imaging using (64)Cu-labeled antibody conjugates, NOTA and sar-CO2H show significant advantages over the others in that they can be radiolabeled rapidly at room temperature, under dilute conditions, resulting in high specific activity.
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'Click' cycloaddition catalysts: copper(I) and copper(II) tris(triazolylmethyl)amine complexes.
TL;DR: The CuI complex of the ' click' ligand tris(benzyltriazolylmethyl)amine is an unusual dinuclear dication with one triazole unit bridging two metal centers, and is an effective catalyst for the 'click' cycloaddition reaction.
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Selective Intracellular Release of Copper and Zinc Ions from Bis(thiosemicarbazonato) Complexes Reduces Levels of Alzheimer Disease Amyloid-β Peptide
Paul S. Donnelly,Aphrodite Caragounis,Aphrodite Caragounis,Tai Du,Tai Du,Katrina M. Laughton,Katrina M. Laughton,Irene Volitakis,Irene Volitakis,Robert A. Cherny,Robert A. Cherny,Robyn A. Sharples,Andrew F. Hill,Qiao-Xin Li,Qiao-Xin Li,Colin L. Masters,Colin L. Masters,Kevin J. Barnham,Kevin J. Barnham,Anthony R. White,Anthony R. White +20 more
TL;DR: It is demonstrated that MII(btsc) complexes have potential for Alzheimer disease therapy and a role for alternative metal-induced Aβ metabolism has not been ruled out.