P
Payal Kapur
Researcher at University of Texas Southwestern Medical Center
Publications - 244
Citations - 11224
Payal Kapur is an academic researcher from University of Texas Southwestern Medical Center. The author has contributed to research in topics: Clear cell renal cell carcinoma & Cancer. The author has an hindex of 42, co-authored 223 publications receiving 8743 citations. Previous affiliations of Payal Kapur include University of Texas at Dallas & University of California, Berkeley.
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Journal ArticleDOI
High-throughput simultaneous screen and counterscreen identifies homoharringtonine as synthetic lethal with von Hippel-Lindau loss in renal cell carcinoma.
Nicholas C. Wolff,Andrea Pavia-Jimenez,Vanina Tcheuyap,Shane Alexander,Mridula Vishwanath,Alana Christie,Xian Jin Xie,Noelle S. Williams,Payal Kapur,Bruce A. Posner,Renée M. McKay,James Brugarolas +11 more
TL;DR: Building on a novel screening strategy and utilizing a validated RCC tumorgraft model recapitulating the genetics and drug responsiveness of human RCC, these studies identify HHT as a potential therapeutic agent for a subset of VHL-deficient ccRCCs.
Journal ArticleDOI
Intratumor Heterogeneity of Perfusion and Diffusion in Clear-Cell Renal Cell Carcinoma: Correlation With Tumor Cellularity.
Qing Yuan,Payal Kapur,Yue Zhang,Yin Xi,Ingrid Carvo,Sabina Signoretti,Ivan E. Dimitrov,Ivan E. Dimitrov,Jeffrey A. Cadeddu,Vitaly Margulis,James Brugarolas,Ananth J. Madhuranthakam,Ivan Pedrosa +12 more
TL;DR: Tumor areas with high ASL perfusion exhibit higher cellularity and MVD compared to areas with low perfusion in the same tumor, and a negative correlation between tumor diffusion and cellularity is confirmed.
Journal ArticleDOI
Activation of sphingosine kinase by lipopolysaccharide promotes prostate cancer cell invasion and metastasis via SphK1/S1PR4/matriptase
Cheng-Fan Lee,Cheng-Fan Lee,Andrew Dang,Elizabeth Hernandez,Rey-Chen Pong,Benjamin P C Chen,Rajni Sonavane,Ganesh V. Raj,Payal Kapur,Hsin-Ying Lin,Shang-Ru Wu,Chun-Jung Ko,Chun-Jung Ko,U-Ging Lo,Hsinyu Lee,Jer Tsong Hsieh,Ming-Shyue Lee +16 more
TL;DR: The results provide not only a new finding of the role of bacterial infection in PCa progression but also potential therapeutic target(s) associated with PCa metastasis.
Journal ArticleDOI
Bilharzial vs non-bilharzial related bladder cancer: pathological characteristics and value of cyclooxygenase-2 expression
Ramy F. Youssef,Payal Kapur,Wareef Kabbani,Shahrokh F. Shariat,Ahmed Mosbah,Hassan Abol-Enein,Mohamed Ghoniem,Yair Lotan +7 more
TL;DR: Study Type – Prognostic (case series) Level of Evidence 4
Journal ArticleDOI
Histone lysine demethylase KDM4B regulates the alternative splicing of the androgen receptor in response to androgen deprivation.
Lingling Duan,Zhenhua Chen,Jun Lu,Yanping Liang,Ming Wang,Carlos M. Roggero,Qing Jun Zhang,Jason Gao,Yong Fang,Jiazheng Cao,Jian Lu,Hongwei Zhao,Andrew Dang,Rey Chen Pong,Elizabeth Hernandez,Chun Mien Chang,David T. Hoang,Jung-Mo Ahn,Guanghua Xiao,Rui Tao Wang,Kai Jiang Yu,Payal Kapur,Josep Rizo,Jer Tsong Hsieh,Junhang Luo,Zhi Ping Liu +25 more
TL;DR: KDM4B-regulated alternative splicing is defined as a pivotal mechanism for generating AR-V7 and a contributing factor for CRPC, providing insight for mechanistic targeting of CRPC.