P
Pedro L. Oliveira
Researcher at Federal University of Rio de Janeiro
Publications - 122
Citations - 6398
Pedro L. Oliveira is an academic researcher from Federal University of Rio de Janeiro. The author has contributed to research in topics: Rhodnius prolixus & Heme. The author has an hindex of 44, co-authored 112 publications receiving 5565 citations. Previous affiliations of Pedro L. Oliveira include Johns Hopkins University.
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Journal ArticleDOI
Characterization of heme as activator of Toll-like receptor 4.
Rodrigo T. Figueiredo,Patricia L. Fernández,Diego Mourão-Sá,Bárbara N. Porto,Fabianno F. Dutra,Letícia S. Alves,Marcus F. Oliveira,Pedro L. Oliveira,Aurélio V. Graça-Souza,Marcelo T. Bozza +9 more
TL;DR: It is demonstrated that heme, but not its analogs/precursors, induced tumor necrosis factor-α (TNF-α) secretion by macrophages dependently on MyD88, TLR4, and CD14, and these findings support the concept that the broad ligand specificity ofTLR4 and the different activation profiles might in part reside in its ability to recognize different ligands in different binding sites.
Journal ArticleDOI
Genome of Rhodnius prolixus, an insect vector of Chagas disease, reveals unique adaptations to hematophagy and parasite infection
Rafael D. Mesquita,Raquel J. Vionette-Amaral,Carl Lowenberger,Rolando Rivera-Pomar,Fernando A. Monteiro,Fernando A. Monteiro,Patrick Minx,John Spieth,A. Bernardo Carvalho,Francisco Panzera,Daniel Lawson,André Q. Torres,André Q. Torres,José M. C. Ribeiro,Marcos Henrique Ferreira Sorgine,Robert M. Waterhouse,Michael J. Montague,Fernando Abad-Franch,Michele Alves-Bezerra,Laurence Rodrigues do Amaral,Helena Araujo,Ricardo Nascimento Araújo,Ricardo Nascimento Araújo,L. Aravind,Georgia C. Atella,Patrícia Azambuja,Patrícia Azambuja,Mateus Berni,Paula R. Bittencourt-Cunha,Glória R.C. Braz,Gustavo M. Calderón-Fernández,Claudia M. A. Carareto,Mikkel B. Christensen,Igor Rodrigues da Costa,Samara G. da Costa,Marilvia Dansa,Carlos R. O. Daumas-Filho,Iron F. De-Paula,Felipe A. Dias,George Dimopoulos,Scott J. Emrich,Natalia Esponda-Behrens,Patrícia Fampa,Rita D. Fernandez-Medina,Rodrigo Nunes da Fonseca,Marcio Fontenele,Catrina Fronick,Lucinda Fulton,Ana Caroline P. Gandara,Eloi S. Garcia,Eloi S. Garcia,Fernando A. Genta,Fernando A. Genta,Gloria I. Giraldo-Calderón,Bruno Gomes,Bruno Gomes,Katia C. Gondim,Adriana Granzotto,Alessandra A. Guarneri,Alessandra A. Guarneri,Roderic Guigó,Myriam Harry,Daniel S.T. Hughes,Willy Jablonka,Emmanuelle Jacquin-Joly,M. Patricia Juárez,Leonardo Koerich,Angela B. Lange,Jose Manuel Latorre-Estivalis,Jose Manuel Latorre-Estivalis,Andrés Lavore,Gena G. Lawrence,Gena G. Lawrence,Cristiano Lazoski,Claudio R. Lazzari,Raphael R.S. Lopes,Marcelo G. Lorenzo,Marcelo G. Lorenzo,Magda D. Lugon,David Majerowicz,Paula L. Marcet,Marco Mariotti,Hatisaburo Masuda,Karyn Megy,Ana C.A. Melo,Fanis Missirlis,Theo Mota,Fernando G. Noriega,Marcela Nouzova,Rodrigo Dutra Nunes,Raquel L.L. Oliveira,Gilbert Oliveira-Silveira,Sheila Ons,Ian Orchard,Lucia Pagola,Gabriela O. Paiva-Silva,Agustina Pascual,Márcio G. Pavan,Nicolás Pedrini,Alexandre A. Peixoto,Alexandre A. Peixoto,Marcos H. Pereira,Marcos H. Pereira,Andrew Pike,Carla Polycarpo,Francisco Prosdocimi,Rodrigo Ribeiro-Rodrigues,Hugh M. Robertson,Ana Paula Salerno,Didier Salmon,Didac Santesmasses,Renata Schama,Renata Schama,Eloy S. Seabra-Junior,Lívia Silva-Cardoso,Mário A.C. Silva-Neto,Matheus Souza-Gomes,Marcos Sterkel,Mabel L. Taracena,Marta Tojo,Zhijian Jake Tu,Jose M. C. Tubio,Raul Ursic-Bedoya,Thiago M. Venancio,Thiago M. Venancio,Ana Beatriz Walter-Nuno,Derek Wilson,Wesley C. Warren,Richard K. Wilson,Erwin Huebner,Ellen M. Dotson,Pedro L. Oliveira +131 more
TL;DR: The first genome sequence of a nondipteran insect vector of an important human parasitic disease is described, which provides critical information on the physiology and evolution of this important vector species and should be instrumental for the development of innovative disease control methods.
Journal ArticleDOI
Adaptations against heme toxicity in blood-feeding arthropods
Aurélio V. Graça-Souza,Clarissa M. Maya-Monteiro,Gabriela O. Paiva-Silva,Glória R.C. Braz,Marcia Cristina Paes,Marcos Henrique Ferreira Sorgine,Marcus F. Oliveira,Pedro L. Oliveira +7 more
TL;DR: In this paper, the authors review mechanisms by which heme can exert biological damage, together with a wide spectrum of adaptations developed by blood-feeding insects and ticks to counteract its deleterious effects.
Journal ArticleDOI
Neutrophil activation by heme: implications for inflammatory processes.
Aurélio V. Graça-Souza,Maria Augusta Arruda,Marta S. De Freitas,Christina Barja-Fidalgo,Pedro L. Oliveira +4 more
TL;DR: A role for hemin as a proinflammatory agent able to induce polymorphonuclear neutrophil activation in situations of clinical relevance, such as hemolysis or hemoglobinemia is suggested.
Journal ArticleDOI
Blood Meal-Derived Heme Decreases ROS Levels in the Midgut of Aedes aegypti and Allows Proliferation of Intestinal Microbiota
Jose Henrique M. Oliveira,Renata L.S. Goncalves,Flávio Alves Lara,Felipe A. Dias,Ana Caroline P. Gandara,Rubem F. S. Menna-Barreto,Meredith C. Edwards,Francisco R.M. Laurindo,Mário A.C. Silva-Neto,Marcos Henrique Ferreira Sorgine,Pedro L. Oliveira +10 more
TL;DR: It is proposed that a controlled decrease in ROS levels in the midgut of Aedes aegypti is an adaptation to compensate for the ingestion of heme, a pro-oxidant molecule released in large amounts upon hemoglobin degradation, which would represent a burden to the insect.