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Shih Shih Chen
Researcher at Ohio State University
Publications - 6
Citations - 769
Shih Shih Chen is an academic researcher from Ohio State University. The author has contributed to research in topics: Chronic lymphocytic leukemia & Epigenetics. The author has an hindex of 6, co-authored 6 publications receiving 746 citations. Previous affiliations of Shih Shih Chen include The Feinstein Institute for Medical Research.
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Journal ArticleDOI
Downregulation of death-associated protein kinase 1 (DAPK1) in chronic lymphocytic leukemia.
Aparna Raval,Stephan M. Tanner,John C. Byrd,Elizabeth Angerman,James D. Perko,Shih Shih Chen,Björn Hackanson,Björn Hackanson,Michael R. Grever,David M. Lucas,Jennifer J. Matkovic,Thomas S. Lin,Thomas J. Kipps,Fiona Murray,Dennis D. Weisenburger,Warren G. Sanger,Jane F. Lynch,Patrice Watson,Mary Jansen,Yuko Yoshinaga,Richard Rosenquist,Pieter J. de Jong,Penny Coggill,Stephan Beck,Henry T. Lynch,Albert de la Chapelle,Christoph Plass +26 more
TL;DR: In this article, the authors show that loss or reduced expression of death-associated protein kinase 1 (DAPK1) underlies cases of heritable predisposition to CLL and the majority of sporadic CLL cases.
Journal ArticleDOI
Epigenetic Modification of CCAAT/Enhancer Binding Protein α Expression in Acute Myeloid Leukemia
Björn Hackanson,Kristi L. Bennett,Romulo M. Brena,Jinmai Jiang,Rainer Claus,Rainer Claus,Shih Shih Chen,Nadya Blagitko-Dorfs,Katie Maharry,Katie Maharry,Susan P. Whitman,Thomas D. Schmittgen,Michael Lübbert,Guido Marcucci,Clara D. Bloomfield,Christoph Plass +15 more
TL;DR: It is shown that C/EBP alpha mRNA is a target for miRNA-124a, a computational microRNA prediction approach and functional studies that shows that this miRNA is frequently silenced by epigenetic mechanisms in leukemia cell lines, becomes up-regulated after epigenetic treatment, and targets the C/ EBP alpha 3' untranslated region.
Journal ArticleDOI
CpG island methylation and expression of the secreted frizzled-related protein gene family in chronic lymphocytic leukemia.
TL;DR: The results suggest that silencing of SFRPs by CpG island methylation is one possible mechanism contributing to aberrant activation of Wnt signaling pathway in CLL.
Journal ArticleDOI
Silencing of the inhibitor of DNA binding protein 4 (ID4) contributes to the pathogenesis of mouse and human CLL
Shih Shih Chen,Rainer Claus,David M. Lucas,Lianbo Yu,Jiang Qian,Amy S. Ruppert,Derek A. West,Katie Williams,Amy J. Johnson,Fred Sablitzky,Christoph Plass,John C. Byrd +11 more
TL;DR: It is demonstrated that the promoter of ID4 is consistently methylated to various degrees in CLL cells, and increased promoter methylation in a univariable analysis correlates with shortened patient survival.
Journal ArticleDOI
Restriction Landmark Genomic Scanning (RLGS) spot identification by second generation virtual RLGS in multiple genomes with multiple enzyme combinations
Dominic J. Smiraglia,Ramakrishnan Kazhiyur-Mannar,Christopher C. Oakes,Yue Zhong Wu,Ping Liang,Tahmina Ansari,Jian Su,Laura J. Rush,Laura T. Smith,Li Yu,Chunhui Liu,Zunyan Dai,Shih Shih Chen,Shu Huei Wang,Joseph F. Costello,Ilya Ioshikhes,David W. Dawson,Jason S. Hong,Michael A. Teitell,Angela Szafranek,Marta Camoriano,Fei Song,Rosemary W. Elliott,William A. Held,Jacquetta M. Trasler,Christoph Plass,Rephael Wenger +26 more
TL;DR: The development of a virtual RLGS method that allows for RLGS spot identification in any sequenced genome and with any enzyme combination and a method to filter the virtual spots to reduce the number of extra spots seen on a virtual profile for both the mouse and human genomes are reported.