P
Peter Arner
Researcher at Karolinska Institutet
Publications - 565
Citations - 56932
Peter Arner is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Adipose tissue & Lipolysis. The author has an hindex of 114, co-authored 553 publications receiving 52710 citations. Previous affiliations of Peter Arner include Karolinska University Hospital & Bristol-Myers Squibb.
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Journal ArticleDOI
A Human-Specific Role of Cell Death-Inducing DFFA (DNA Fragmentation Factor-α)-Like Effector A (CIDEA) in Adipocyte Lipolysis and Obesity
Elisabet Arvidsson Nordström,Mikael Rydén,Emma C. Backlund,Ingrid Dahlman,Maria Kaaman,Lennart Blomqvist,Barbara Cannon,Jan Nedergaard,Peter Arner +8 more
TL;DR: An important and human-specific role is proposed for CIDEA in lipolysis regulation and metabolic complications of obesity, which is at least in part mediated by cross-talk between CideA and TNF-alpha.
Journal ArticleDOI
Automatic luminometric kinetic assay of glycerol for lipolysis studies.
TL;DR: The analytical performance and degree of automation of the glycerol method makes it well suited for serial studies oflipolysis in human fat cells in the presence of lipolytic or antilipolytic agents.
Journal ArticleDOI
Downregulation of Electron Transport Chain Genes in Visceral Adipose Tissue in Type 2 Diabetes Independent of Obesity and Possibly Involving Tumor Necrosis Factor-α
Ingrid Dahlman,Margaretha Forsgren,Annelie Sjögren,Elisabet Arvidsson Nordström,Maria Kaaman,Erik Näslund,Anneli Attersand,Peter Arner +7 more
TL;DR: Type 2 diabetes is associated with a tissue- and region-specific downregulation of oxidative phosphorylation genes that is independent of obesity and at least in part mediated by TNF-α, suggesting that impaired oxidative phosphORYlation of visceral adipose tissue has pathogenic importance for development of type 2 diabetes.
Journal Article
Regulation of lipolysis in humans. Pathophysiological modulation in obesity, diabetes, and hyperlipidaemia.
V Large,Peter Arner +1 more
TL;DR: New advances in genetic studies indicate that polymorphisms in several genes encoding for proteins that regulate the lipolysis process are important for the development of obesity and its complications.
Journal ArticleDOI
Different aetiologies of type 2 (non-insulin-dependent) diabetes mellitus in obese and non-obese subjects.
TL;DR: Type 2 diabetes in obese and non-obese elderly male subjects may take two forms where the cause of hyperglycaemia differs, as indicated by insulin responses to intravenous glucose infusion and glucose utilization during hyperinsulinaemic euglycaemic clamp.