P
Peter Arner
Researcher at Karolinska Institutet
Publications - 565
Citations - 56932
Peter Arner is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Adipose tissue & Lipolysis. The author has an hindex of 114, co-authored 553 publications receiving 52710 citations. Previous affiliations of Peter Arner include Karolinska University Hospital & Bristol-Myers Squibb.
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Journal ArticleDOI
A Common Hormone-Sensitive Lipase i6 Gene Polymorphism Is Associated With Decreased Human Adipocyte Lipolytic Function
Johan Hoffstedt,Peter Arner,Martin Schalling,Nancy L. Pedersen,Selim Sengul,Susanne Ahlberg,Anastasia Iliadou,Catharina Lavebratt +7 more
TL;DR: It is concluded that allele 5 of the HSLi6 polymorphism is associated with a marked decrease in the lipolytic rate of abdominal fat cells, which may in turn contribute to the development of obesity.
Journal ArticleDOI
Twist1 in human white adipose tissue and obesity.
Amanda T. Pettersson,Niklas Mejhert,Margareta Jernås,Lena M. S. Carlsson,Ingrid Dahlman,Jurga Laurencikiene,Peter Arner,Mikael Rydén +7 more
TL;DR: Low twist1 expression in human WAT correlates with obesity and an insulin-resistant phenotype, which may be mediated by an increased sensitivity to the proinflammatory effect of TNFα.
Journal ArticleDOI
Several obesity- and nutrient-related gene polymorphisms but not FTO and UCP variants modulate postabsorptive resting energy expenditure and fat-induced thermogenesis in obese individuals: the NUGENOB study.
Gijs H. Goossens,Liselotte Petersen,Ellen E. Blaak,Gabby B. Hul,Peter Arner,Arne Astrup,Philippe Froguel,Kishor Patel,Oluf Pedersen,Joseph F. Polak,J.-M. Oppert,José Alfredo Martínez,T I A Sørensen,Wim H. M. Saris +13 more
TL;DR: Several gene polymorphisms associated with obesity-related phenotypes but not FTO and UCP variants may be responsible for some of the inter-individual variability in postabsorptive REE and fat-induced thermogenesis unaccounted for by FFM, FM, age and sex.
A Possible Inflammatory Role of Twist1 in Human White
Adipocytes T. Pettersson,Jurga Laurencikiene,Niklas Mejhert,Anne Bouloumié,Ingrid Dahlman,Peter Arner +5 more
TL;DR: Twin1 may play a role in inflammation of human WAT because it can regulate the expression and secretion of inflammatory adipokines via direct transcriptional effects in white adipocytes and may, in contrast to findings in mice, be a positive regulator of fatty acid oxidation in humanwhite adipocytes.
Journal ArticleDOI
Influence of adipocyte isolation by collagenase on phosphodiesterase activity and lipolysis in man
TL;DR: It is concluded that the greater lipolytic response of collagenase-isolated adipocytes than of tissue fragments to catecholamines may be attributed, at least in some measure, to the higher concentration of cyclic AMP resulting from a decrease in PDE activity.