P
Peter Arner
Researcher at Karolinska Institutet
Publications - 565
Citations - 56932
Peter Arner is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Adipose tissue & Lipolysis. The author has an hindex of 114, co-authored 553 publications receiving 52710 citations. Previous affiliations of Peter Arner include Karolinska University Hospital & Bristol-Myers Squibb.
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Systemic nicotine stimulates human adipose tissue lipolysis through local cholinergic and catecholaminergic receptors
Kurt Andersson,Peter Arner +1 more
TL;DR: Systemically administered nicotine induces lipolysis, in part by activating the classical adrenergic mechanism (mediated by a nicotine-induced release of catecholamines stimulating beta-adrenoceptors), and in partBy directly activating a nicotinic cholinergic lipolytic receptor located in adipose tissue.
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The Adipocyte, Fatty Acid Trapping, and Atherogenesis
TL;DR: It is postulate that failure to trap the normal proportion of dietary fatty acids in adipocytes leads to their abnormal diversion to liver and muscle, and from this abnormal diversion stems the complex array of metabolic alterations listed above that so markedly increase the risk of vascular disease in patients.
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Lipid and glucose metabolism in white adipocytes: pathways, dysfunction and therapeutics
TL;DR: In this paper, the importance of white adipocyte hypertrophy and the interplay between metabolic pathways explains the fine-tuning between the anabolic and catabolic fates of fatty acids and glucose in different physiological states.
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Regulation of lipolysis in small and large fat cells of the same subject.
Jurga Laurencikiene,Thomas Skurk,Agné Kulyté,Per Hedén,Gaby Åström,Eva Sjölin,Mikael Rydén,Hans Hauner,Peter Arner +8 more
TL;DR: Independently of the donor, fat cell size per se determines lipolysis rates, probably due to the enrichment of regulatory proteins distal in the lipolytic cascade, to which alllipolytic signals converge (lipases and perilipin).
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Drug distribution studies with microdialysis. III: Extracellular concentration of caffeine in adipose tissue in man.
TL;DR: It is concluded that microdialysis yield useful data on drug distribution in man and that distribution to adipose tissue may not strictly follow the concentrations in blood.