P
Peter Arner
Researcher at Karolinska Institutet
Publications - 565
Citations - 56932
Peter Arner is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Adipose tissue & Lipolysis. The author has an hindex of 114, co-authored 553 publications receiving 52710 citations. Previous affiliations of Peter Arner include Karolinska University Hospital & Bristol-Myers Squibb.
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Journal ArticleDOI
Polymorphism in the Calpain 10 gene influences glucose metabolism in human fat cells.
TL;DR: The Calpain 10 gene could be involved in the regulation of glucose metabolism but not lipolysis in human fat cells, although it does not involve adipocyte GLUT-4 protein content.
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Association of a beta-2 adrenoceptor ( ADRB2 ) gene variant with a blunted in vivo lipolysis and fat oxidation
Johan W. E. Jocken,Ellen E. Blaak,S.L.H. Schiffelers,Peter Arner,M. A. van Baak,Wim H. M. Saris +5 more
TL;DR: Genetic variation in the ADRB2 gene is associated with disturbances in in vivo β-adrenoceptor-mediated lipolysis and fat oxidation during β- adrenergic stimulation in overweight and obese subjects; these effects are influenced by gene–gender interactions.
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Adrenergic regulation of lipolysis in human fat cells during exercise.
TL;DR: The increased beta‐adrenergic responsiveness induced by exercise in gluteal adipocytes of males could be mimicked by agents acting at the levels of adenylate cyclase, coupling proteins, phosphodiesterase, and protein kinase and seems to be due to an adaptive enhancement at the hormone‐sensitive‐lipase level.
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The Arg 389 Gly beta1-adrenergic receptor gene polymorphism and human fat cell lipolysis.
TL;DR: The distribution of the Arg 389 Gly polymorphism is similar in lean and obese subjects and has no apparent effect on the lipolytic response to β-adrenergic stimulation in native human adipocytes, suggesting that the Arg 386 Gly polymorphisms has no important influence on human obesity.
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The effect of the beta2 adrenoceptor gene Thr164Ile polymorphism on human adipose tissue lipolytic function
TL;DR: A rare β2-adrenoceptor gene polymorphism, Thr164Ile, has been described that impairs receptor function when transfected into cell lines as discussed by the authors.