P
Peter Arner
Researcher at Karolinska Institutet
Publications - 565
Citations - 56932
Peter Arner is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Adipose tissue & Lipolysis. The author has an hindex of 114, co-authored 553 publications receiving 52710 citations. Previous affiliations of Peter Arner include Karolinska University Hospital & Bristol-Myers Squibb.
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Journal ArticleDOI
Human White Adipose Tissue Displays Selective Insulin Resistance in the Obese State
Enrichetta Mileti,Kelvin Ho Man Kwok,Daniel P. Andersson,Anthony Mathelier,Anthony Mathelier,Amitha Raman,Jesper Bäckdahl,Jutta Jalkanen,Lucas Massier,Anders Thorell,Hui Gao,Peter Arner,Niklas Mejhert,Carsten O. Daub,Carsten O. Daub,Mikael Rydén +15 more
TL;DR: Human WAT displays a selective insulin response in the obese state, where most genes are normalized by weight loss, and this comprehensive atlas provides insights into the transcriptional effects of insulin in WAT and may identify targets to improve insulin action.
Journal ArticleDOI
Left ventricular β1 and β2 adrenoceptor mRNA expression in normal and volume overloaded human heart
Christer Sylvén,Peter Arner,L Hellström,Eva Jansson,Péter Sótonyi,André Somogyi,Mikael Brönnegård +6 more
TL;DR: Myocardium from different parts of the normal human heart, where different pressure work is generated, express similar levels of BAR-1 and BAR-2 mRNA, which indicates an independent regulation of the expression of these two receptor subtypes.
Journal ArticleDOI
Determination of adrenoceptors of the alpha2-subtype on isolated human fat cells
TL;DR: It is concluded that the (3H)-yohimbine method can be used for the study of alpha 2-receptor properties and regulation in subcutaneous adipose tissue in a given individual.
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Allele-specific quantitative proteomics unravels molecular mechanisms modulated by cis-regulatory PPARG locus variation.
Heekyoung Lee,Kun Qian,Christine von Toerne,Lena Hoerburger,Melina Claussnitzer,Christoph Hoffmann,Viktoria Glunk,Simone Wahl,Michaela Breier,Franziska Eck,Leili Jafari,Sophie Molnos,Harald Grallert,Ingrid Dahlman,Peter Arner,Cornelia Brunner,Hans Hauner,Stefanie M. Hauck,Helmut Laumen +18 more
TL;DR: Combining bioinformatics and public domain chromatin information with quantitative proteomics supports prediction of cis-regulatory variants and enabled identification of allele-dependent binding of both, transcription factors and coregulators at the type 2 diabetes associated PPARG locus.
Journal ArticleDOI
Effect of metoprolol and alprenolol on the metabolic, hormonal, and haemodynamic response to insulin-induced hypoglycaemia in hypertensive, insulin-dependent diabetics.
TL;DR: The haemodynamic response was altered only by the non-selective alprenolol and not by the selective beta-adrenergic blocking agent (metoprolol), and the signs of hypoglycaemia were not masked.