Timothy J. Kendall

TL;DR: Analysis of transcriptomes of more than 100,000 single human cells yields molecular definitions for non-parenchymal cell types that are found in healthy and cirrhotic human liver, and identifies markers for scar-associated macrophages and endothelial cells.

TL;DR: An association between MMP13 expression and the presence of SAMs in the regression of experimental liver fibrosis is demonstrated and SAMs selectively, during resolution of fibrosis induce and use the major collagenase M MP13 to mediate the resorption of interstitial matrix and successfully remodel the fibrotic liver.

TL;DR: A mouse model where the E3 ubiquitin ligase Mdm2 is inducibly deleted in more than 98% of hepatocytes, causing apoptosis, necrosis and senescence with nearly all hepatocytes expressing p21 is described, resulting in florid HPC activation, which is necessary for survival, followed by complete, functional liver reconstitution.

TL;DR: Liver injury, which can be extensive in this patient group, is related to Fontan duration and hepatic vein pressures, and cardiac cirrhosis with the risk of developing gastro-oesophageal varices and regenerative liver nodules, a precursor to hepatocellular carcinoma, is common in this patients.

TL;DR: HSC apoptosis plays a critical role in the spontaneous recovery from biliary fibrosis and survival and apoptosis are regulated by growth factors expressed during fibrotic liver injury.