P
Pius Brzoska
Researcher at Life Technologies
Publications - 43
Citations - 5999
Pius Brzoska is an academic researcher from Life Technologies. The author has contributed to research in topics: Genome & Population. The author has an hindex of 13, co-authored 39 publications receiving 5479 citations. Previous affiliations of Pius Brzoska include Thermo Fisher Scientific & Applied Biosystems.
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Journal ArticleDOI
Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis
Rajnish A. Gupta,Nilay Shah,Kevin C. Wang,Jeewon Kim,Hugo M. Horlings,David J. Wong,Miao-Chih Tsai,Tiffany Hung,Pedram Argani,John L. Rinn,Yulei Wang,Pius Brzoska,Benjamin Kong,Rui-Chun Li,Robert B. West,Marc J. van de Vijver,Saraswati Sukumar,Howard Y. Chang +17 more
TL;DR: It is shown that lincRNAs in the HOX loci become systematically dysregulated during breast cancer progression, indicating that l incRNAs have active roles in modulating the cancer epigenome and may be important targets for cancer diagnosis and therapy.
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Prospective Genomic Characterization of the German Enterohemorrhagic Escherichia coli O104:H4 Outbreak by Rapid Next Generation Sequencing Technology
Alexander Mellmann,Dag Harmsen,Craig Cummings,Emily B. Zentz,Shana R. Leopold,Alain Rico,Karola Prior,Rafael Szczepanowski,Yongmei Ji,Wenlan Zhang,Stephen F. McLaughlin,John K. Henkhaus,Benjamin Leopold,Martina Bielaszewska,Rita Prager,Pius Brzoska,Richard Moore,Simone Guenther,Jonathan M. Rothberg,Helge Karch +19 more
TL;DR: It is suggested that by stepwise gain and loss of chromosomal and plasmid-encoded virulence factors, a highly pathogenic hybrid of EAEC and EHEC emerged as the current outbreak clone.
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Tumor transcriptome sequencing reveals allelic expression imbalances associated with copy number alterations.
Brian B. Tuch,Rebecca R. Laborde,Xing Xu,Jian Gu,Christina A. Bormann Chung,Cinna Monighetti,Sarah Stanley,Kerry D. Olsen,Jan L. Kasperbauer,Eric J. Moore,Adam J. Broomer,Ruoying Tan,Pius Brzoska,Matthew W. Muller,Asim Siddiqui,Yan W. Asmann,Yongming Sun,Scott Kuersten,Melissa Barker,Francisco M. De La Vega,David I. Smith +20 more
TL;DR: It is found that allelic imbalance in the tumor is associated with Copy number mutations and that copy number mutations are, in turn, strongly associated with changes in transcript abundance, which support a model in which allele-specific deletions and duplications drive allele- specific changes in gene expression in the developing tumor.
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Comparative Analysis of Genome Sequences Covering the Seven Cronobacter Species
Susan Joseph,Prerak T. Desai,Yongmei Ji,Craig Cummings,Rita Shih,Lovorka Degoricija,Alain Rico,Pius Brzoska,Stephen E. Hamby,Naqash Masood,Sumyya Hariri,Hana Sonbol,Nadia Chuzhanova,Michael McClelland,Manohar R. Furtado,Stephen J. Forsythe +15 more
TL;DR: C. sakazakii is unique in the Cronobacter genus in encoding genes enabling the utilization of exogenous sialic acid which may have clinical significance, and also suggested various degrees of divergence.
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Developmental validation of the Quantifiler(®) HP and Trio Kits for human DNA quantification in forensic samples.
TL;DR: The Quantifiler HP and Trio Kits' improved performance provides better predictive ability for results with downstream, newest-generation STR assays, and their shortened time-to-result allows more efficient integration into the forensic casework analysis workflow.