Statistical method for testing the neutral mutation hypothesis by DNA polymorphism.

Microbial decolouration of azo dyes: a review.

Gallbladder cancer is a malignancy of biliary tract which is infrequent in developed countries but common in some specific geographical regions of developing countries. Late diagnosis and deprived prognosis are major problems for treatment of gallbladder carcinoma. The dramatic associations of this orphan cancer with various genetic and environmental factors are responsible for its poorly defined pathogenesis. An understanding to the relationship between epidemiology, molecular genetics and pathogenesis of gallbladder cancer can add new insights to its undetermined pathophysiology. Present review article provides a recent update regarding epidemiology, pathogenesis, and molecular genetics of gallbladder cancer. We systematically reviewed published literature on gallbladder cancer from online search engine PubMed (http://www.ncbi.nlm.nih.gov/pubmed). Various keywords used for retrieval of articles were Gallbladder, cancer Epidemiology, molecular genetics and bullion operators like AND, OR, NOT. Cross references were manually searched from various online search engines (http://www.ncbi.nlm.nih.gov/pubmed,https://scholar.google.co.in/, http://www.medline.com/home.jsp). Most of the articles published from 1982 to 2015 in peer reviewed journals have been included in this review.

Gallbladder cancer epidemiology, pathogenesis and molecular genetics: Recent update.

LncRNA HOXA-AS2 and its molecular mechanisms in human cancer.

Discharge of untreated domestic and industrial wastewater into aquatic bodies is posing a serious eutrophication threat, leading to a slow degradation of the water resources. A number of physical, chemical and biological methods have been developed for the treatment of wastewaters; among these, the use of microalgae is considered as a more eco-friendly and economical approaches. Microalgae are versatile organisms which perform multiple roles in the environment—bioremediation of wastewater, gleaning of excess nutrients and in turn, generate valuable biomass which finds applications in the food, biofuel and pharmaceutical industries. They are currently being utilized to reduce the high nutrient load (especially N and P) from wastewaters, which fulfill the growth requirements of microalgae, making it a suitable cultivation medium for biomass production. The present review represents a comprehensive compilation of reports on microalgal diversity of wastewaters, followed by a critical overview of their utilization, suitability and potential in bioremediation vis-a-vis biomass production. This review also emphasizes the superiority of polyalgal and consortial approaches in wastewater treatment, as compared to the use of unialgal inocula, besides providing useful pointers for future research needs in this area.

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Phycoremediation of wastewaters: a synergistic approach using microalgae for bioremediation and biomass generation

Gallbladder cancer (GBC) is associated with various nongenetic and genetic factors. Lack of specific and sensitive diagnostic markers has significantly impacted the mortality of this disease. Here we discuss the recent discovery of epigenetic changes that show great promise as diagnostic biomarkers as well as potential therapeutic targets for GBC.

Epigenetic Biomarkers in Gallbladder Cancer.

Aim of Study: To investigate the trend of expression of liver function test enzymes and other biochemical changes during gallbladder carcinogenesis. Materials and Methods: Eight hundred and seventy-eight gallbladder disease patients were selected to study the liver function test enzymes and routine blood biochemical changes in the last five years (2004-08). Statistical analysis was performed using Graph Pad prism® 5.02 software. Results: The liver function test enzymes showed significant correlations among themselves, and with glucose in gallbladder cancer and gallstone disease patients (N = 878). Out of 878 gallbladder cases, 46 (5.24%) showed significantly higher glucose level of 216.66 mg/dL (P < 0.0001). All the three pathological conditions of gallbladder, gallbladder cancer with stones (GBCS), gallbladder cancer without stones (GBC) and calculus cholecystitis (CC), showed highly significant positive correlation (Pearson) between Serum Glutamic Oxaloactetic Transaminase (SGOT) and Serum Glutamic Pyruvic Transaminase (SGPT) [P < 0.0001, (GBCS); P < 0.0001, (GBC), and P < 0.0001, (CC)]. SGOT and SGPT also showed positive correlation with higher glucose level independently, in both GBCS and CC (P < 0.0001 and P < 0.0001), respectively. Conclusion: Simultaneous elevation of glucose and liver function test enzymes in GBC makes the diagnosis complex. Any patient of gallbladder diseases with higher level of glucose may have the possibility of developing gallbladder cancer.

The liver function test enzymes and glucose level are positively correlated in gallbladder cancer: a cancer registry data analysis from north central India.

In this paper, an analytical threshold voltage model is developed for a short-channel double-material-gate (DMG) strained-silicon (s-Si) on silicon-germanium (Si 1-x Ge x ) MOSFET structure. The proposed threshold voltage model is based on the so called virtual-cathode potential formulation. The virtual-cathode potential is taken as minimum channel potential along the transverse direction of the channel and is derived from tow-dimensional (2D) potential distribution of channel region. The (2D) potential distribution of channel region. The 2D channel potential is formulated by solving the 2D Poisson"s equation with suitable boundary conditions in both the strained-Si layer and relaxed Si 1-x Ge x layer. The effects of a number of device parameters like the Ge mole fraction, Si film thickness and gate-length ratio have been considered on threshold voltage. Further, the drain induced barrier lowering (DIBL) has also been analyzed for gate-length ratio and amount of strain variations. The validity of the present 2D analytical model is verified with ATLAS TM , a 2D device simulator from Silvaco Inc.

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An Analytical Model for the Threshold Voltage of Short-Channel Double-Material-Gate (DMG) MOSFETs with a Strained-Silicon (s-Si) Channel on Silicon-Germanium (SiGe) Substrates

The effect of two most commonly used and highly toxic organic pesticides, endosulphan (organochlorine) and monocrotophos (organophosphate), was studied in a blowfly, Lucilia cuprina, to test whether these pesticides induce the stress response and, if so, whether the intensity of the response, in terms of induction of heat shock proteins (HSPs), HSP60 and HSP70 in particular, is pesticide concentration dependent. The in vitro exposure of larval and adult tissues to varying concentrations of these pesticides (endosulphan: 1.0–4.0 ppm for larva and 0.05–0.50 ppm for adult; monocrotophos: 0.0005–0.0050 ppm for larva and 0.0001–0.0010 ppm for adult) revealed that both compounds were able to induce the expression of HSP60 and HSP70 proteins. Western blot analysis of these HSPs indicated that the induction of expression was tissue-specific. The trypan blue staining of pesticide-exposed tissues demonstrated monocrotophos to exert more severe effect than endosulphan, as the former compound induced both HSP60 and HSP70 significantly at a much lower concentration than that of the later. The pattern of expression of these HSPs, in general, appeared in direct correlation with the pesticide concentration. Gut tissues were found relatively more sensitive to pesticide toxicity than other tissues, as revealed by trypan blue staining, and hence, they might serve as primary targets for early detection of pesticide toxicity. The results indicated that either of these HSPs or both could serve as a potential biomarker toward assessment and monitoring of toxicity induced by these pesticides.

In vitro induction of 60-kDa and 70-kDa heat shock proteins by endosulphan and monocrotophos in sheep blowfly Lucilia cuprina.

\n The dielectric pocket gate-all-around (DPGAA) MOSFET is being considered the best suited candidate for ULSI electronic chips because of excellent electrostatic control over the channel. However, the phenomena of self-heating and hot carrier injection (HCI) severely affect the performance of the device, and make the behaviour of the DPGAA FET very unpredictable. In the present article, a comprehensive investigation under the influence of self-heating effects has been done for the variation in the lattice and carrier temperature against spacer length, ambient temperature, device length, and thermal contact resistance including ON and Off currents with gate bias voltage (VGS). In order to analyse the SHEs, the hydrodynamic (HD) and thermodynamic (TD) transport models have been used for three-dimensional (3D) electrothermal (ET) simulation. The Lucky (hot carrier injection) model has been used to study the HCI degradation in DPGAA MOSFET using Sentaurus 3D TCAD simulator.

/pdf/investigating-the-impact-of-self-heating-effects-on-some-2r72gc98pq.pdf

Pramod Kumar Tiwari

Papers

Epigenetic Biomarkers in Gallbladder Cancer.

The liver function test enzymes and glucose level are positively correlated in gallbladder cancer: a cancer registry data analysis from north central India.

An Analytical Model for the Threshold Voltage of Short-Channel Double-Material-Gate (DMG) MOSFETs with a Strained-Silicon (s-Si) Channel on Silicon-Germanium (SiGe) Substrates

In vitro induction of 60-kDa and 70-kDa heat shock proteins by endosulphan and monocrotophos in sheep blowfly Lucilia cuprina.

Investigating the Impact of Self-Heating Effects on Some Thermal and Electrical Characteristics of Dielectric Pocket Gate-All-Around (DPGAA) MOSFETs