P
Pyry I. Toivanen
Researcher at University of Eastern Finland
Publications - 19
Citations - 537
Pyry I. Toivanen is an academic researcher from University of Eastern Finland. The author has contributed to research in topics: Angiogenesis & Vascular endothelial growth factor. The author has an hindex of 12, co-authored 17 publications receiving 465 citations.
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Journal ArticleDOI
Adenoviral intramyocardial VEGF-DΔNΔC gene transfer increases myocardial perfusion reserve in refractory angina patients: a phase I/IIa study with 1-year follow-up.
Juha Hartikainen,Iiro Hassinen,Antti Hedman,Antti Kivelä,Antti Saraste,Juhani Knuuti,Minna Husso,Hanna Mussalo,Marja Hedman,Tuomas T. Rissanen,Pyry I. Toivanen,Tommi Heikura,Joseph L. Witztum,Sotirios Tsimikas,Seppo Ylä-Herttuala +14 more
TL;DR: Myocardial perfusion increased at 1 year in the treated areas with impaired MPR at baseline, and Plasma Lp(a) may be a potential biomarker to identify patients that may have the greatest benefit with this therapy.
Journal ArticleDOI
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
Veli-Matti Leppänen,Michael Jeltsch,Andrey Anisimov,Denis Tvorogov,Kukka Aho,Nisse Kalkkinen,Pyry I. Toivanen,Seppo Ylä-Herttuala,Kurt Ballmer-Hofer,Kari Alitalo +9 more
TL;DR: A VEGFR-2-specific form of VEGF-D that is angiogenic but not lymphangiogenic is defined, providing important new insights into VEGf-D structure and function.
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A multipurpose vector system for the screening of libraries in bacteria, insect and mammalian cells and expression in vivo
Olli H. Laitinen,Kari J. Airenne,Vesa P. Hytönen,Erik Peltomaa,Anssi J. Mähönen,Thomas Wirth,Miia M. Lind,Kari A. Mäkelä,Pyry I. Toivanen,Diana Schenkwein,Tommi Heikura,Henri R. Nordlund,Markku S. Kulomaa,Seppo Ylä-Herttuala +13 more
TL;DR: The pBVboostFG enables screening of genome-wide libraries, thus making it an efficient new platform technology for functional genomics and a proof-of-principle of using the vector for library screening.
Journal ArticleDOI
Antiangiogenic Gene Therapy With Soluble VEGFR-1, -2, and -3 Reduces the Growth of Solid Human Ovarian Carcinoma in Mice
Hanna Sallinen,Maarit Anttila,Johanna Närväinen,Jonna K. Koponen,Kirsi Hämäläinen,Ivana Kholová,Tommi Heikura,Pyry I. Toivanen,Veli-Matti Kosma,Seppo Heinonen,Kari Alitalo,Seppo Ylä-Herttuala +11 more
TL;DR: The results suggest that the combined antiangiogenic gene therapy with soluble VEGFRs reduced tumor growth, tumor vascularity, and ascites formation in ovarian cancer xenografts.
Journal ArticleDOI
A laboratory-scale device for the straightforward production of uniform, small sized cell microcapsules with long-term cell viability.
Leena-Stiina Kontturi,Marjo Yliperttula,Pyry I. Toivanen,Antti Määttä,Ann-Marie Määttä,Arto Urtti +5 more
TL;DR: A simple, inexpensive and flexible laboratory-scale device for the production of cell microcapsules, especially capsules of small diameter (<300 μm), and an advantage of the present procedure compared to other similar, co-axial laminar gas flow systems is the possibility to produce also small micro Capsules, less than 200 μm in diameter, with narrow size distribution.