Journal ArticleDOI
Structural determinants of vascular endothelial growth factor-D receptor binding and specificity
Veli-Matti Leppänen,Michael Jeltsch,Andrey Anisimov,Denis Tvorogov,Kukka Aho,Nisse Kalkkinen,Pyry I. Toivanen,Seppo Ylä-Herttuala,Kurt Ballmer-Hofer,Kari Alitalo +9 more
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TLDR
A VEGFR-2-specific form of VEGF-D that is angiogenic but not lymphangiogenic is defined, providing important new insights into VEGf-D structure and function.About:
This article is published in Blood.The article was published on 2011-02-03. It has received 82 citations till now. The article focuses on the topics: Vascular Endothelial Growth Factor D & Receptor tyrosine kinase.read more
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Signal Transduction by Vascular Endothelial Growth Factor Receptors
Sina Koch,Lena Claesson-Welsh +1 more
TL;DR: This review outlines the current information on VEGF signal transduction in relation to blood and lymphatic vessel biology and develops treatments to halt blood vessel formation, angiogenesis in diseases that involve tissue growth and inflammation, such as cancer.
Journal ArticleDOI
Signal transduction by vascular endothelial growth factor receptors.
TL;DR: The present review will outline the current understanding and consequent biology of VEGF receptor signalling and Therapeutic agents that interfere with V EGF signalling in diseases that involve tissue growth and inflammation, such as cancer.
Journal ArticleDOI
The lymphatic vasculature in disease
TL;DR: This review highlights the most recent developments in lymphatic biology and how the lymphatic system contributes to the pathogenesis of various diseases involving immune and inflammatory responses and its role in disseminating tumor cells.
Journal ArticleDOI
Interaction of tumor cells and lymphatic vessels in cancer progression
Annamari Alitalo,Michael Detmar +1 more
TL;DR: Current knowledge indicates that the development of anti-lymphangiogenic therapies may be beneficial for the treatment of cancer patients, but several open questions remain with regard to the frequency, mechanisms and biological importance of lymphatic metastases.
Journal ArticleDOI
CCBE1 Enhances Lymphangiogenesis via A Disintegrin and Metalloprotease With Thrombospondin Motifs-3–Mediated Vascular Endothelial Growth Factor-C Activation
Michael Jeltsch,Sawan Kumar Jha,Denis Tvorogov,Andrey Anisimov,Veli-Matti Leppänen,Tanja Holopainen,Riikka Kivelä,Sagrario Ortega,Terhi Karpanen,Kari Alitalo +9 more
TL;DR: The results suggest that CCBE1 is a potential therapeutic tool for the modulation of lymphangiogenesis and angiogenesis in a variety of diseases that involve the lymphatic system, such as lymphedema or lymphatic metastasis.
References
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Coot: model-building tools for molecular graphics.
Paul Emsley,Kevin Cowtan +1 more
TL;DR: CCP4mg is a project that aims to provide a general-purpose tool for structural biologists, providing tools for X-ray structure solution, structure comparison and analysis, and publication-quality graphics.
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The CCP4 suite: programs for protein crystallography
TL;DR: The CCP4 (Collaborative Computational Project, number 4) program suite is a collection of programs and associated data and subroutine libraries which can be used for macromolecular structure determination by X-ray crystallography.
Journal ArticleDOI
Abnormal blood vessel development and lethality in embryos lacking a single VEGF allele
Peter Carmeliet,Valérie Ferreira,Georg Breier,Saskia Pollefeyt,Lena Kieckens,Marina Gertsenstein,Michaela Fahrig,Ann Vandenhoeck,Kendraprasad Harpal,Carmen Eberhardt,Cathérine Declercq,Judy Pawling,Lieve Moons,Desire Collen,Werner Risau,Andras Nagy,Andras Nagy +16 more
TL;DR: It is reported that formation of blood vessels was abnormal, but not abolished, in heterozygous VEGF-deficient (VEGF+/-) embryos, generated by aggregation of embryonic stem (ES) cells with tetraploid embryos (T-ES)16,17, and even more impaired in homozygous D1-VEGF- deficient (VDGF-/-) T-ES embryos, resulting in death at mid-gestation.
Journal ArticleDOI
PHENIX: building new software for automated crystallographic structure determination
Paul D. Adams,Ralf W. Grosse-Kunstleve,Li-Wei Hung,Thomas R. Ioerger,Airlie J. McCoy,Nigel W. Moriarty,Randy J. Read,James C. Sacchettini,Nicholas K. Sauter,Thomas C. Terwilliger +9 more
TL;DR: A novel software package called PHENIX (Python-based Hierarchical ENvironment for Integrated Xtallography) is developed, which will provide the necessary algorithms to proceed from reduced intensity data to a refined molecular model and to facilitate structure solution for both the novice and expert crystallographer.
Journal ArticleDOI
Heterozygous embryonic lethality induced by targeted inactivation of the VEGF gene.
Napoleone Ferrara,Karen Carver-Moore,Helen Hsifei Chen,Mary Dowd,Lucy Lu,K. Sue O'Shea,Lyn Powell-Braxton,Kenneth J. Hillan,Mark W. Moore +8 more
TL;DR: The unexpected finding that loss of a single VEGF allele is lethal in the mouse embryo between days 11 and 12 was reported, and angiogenesis and blood-island formation were impaired, resulting in several developmental anomalies.
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Blocking VEGFR-3 suppresses angiogenic sprouting and vascular network formation
Tuomas Tammela,Georgia Zarkada,Elisabet Wallgard,Aino Murtomäki,Steven Suchting,Maria Wirzenius,Marika Waltari,Mats Hellström,Tibor Schomber,Reetta Peltonen,Catarina Freitas,Antonio Duarte,Helena Isoniemi,Pirjo Laakkonen,Gerhard Christofori,Seppo Ylä-Herttuala,Masabumi Shibuya,Bronislaw Pytowski,Anne Eichmann,Christer Betsholtz,Kari Alitalo +20 more