Open Access
Emergence and spread of a human-transmissible multidrug-resistant nontuberculous mycobacterium
Josephine M. Bryant,Dorothy M Grogono,Daniela Rodriguez-Rincon,Isobel Everall,Karen Brown,Pablo Moreno,Deepshikha Verma,E. Hill,J. Drijkoningen,Peter H. Gilligan,Charles R. Esther,Peadar G. Noone,Olivia Giddings,Scott C. Bell,Rachel Thomson,Claire E. Wainwright,Chris Coulter,Sushil Pandey,Michelle Wood,Rebecca E Stockwell,Kay A. Ramsay,Laura J. Sherrard,Timothy J. Kidd,Nassib Jabbour,Graham R. Johnson,Luke D. Knibbs,Lidia Morawska,Peter D. Sly,Alison Jones,Diana Bilton,Ian F. Laurenson,Michael Ruddy,Stephen Bourke,Ian C. J. W. Bowler,Stephen J Chapman,Andrew Clayton,M. Cullen,Owen J. Dempsey,Miles Denton,M. Desai,R. J. Drew,F. Edenborough,Jason T. Evans,Jonathan Folb,T. Daniels,H. Humphrey,B. Isalska,Søren Jensen-Fangel,Bodil Jönsson,Andrew Jones,Terese L. Katzenstein,Troels Lillebaek,Gordon MacGregor,S. Mayell,Michael Millar,Deborah E. Modha,Edward F. Nash,C. O'Brien,D. OBrien,Chandra Ohri,Caroline S. Pao,Daniel Peckham,Felicity Perrin,Audrey Perry,Tacjana Pressler,L. Prtak,Tavs Qvist,A. Robb,Helen Rodgers,K. Schaffer,Nadia Shafi,J. van Ingen,M. Walshaw,D. Watson,Noreen West,Joanna L. Whitehouse,Charles S. Haworth,Simon R. Harris,Diane J. Ordway,Julian Parkhill,R.A. Floto +80 more
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TLDR
In this paper, the authors used whole-genome analysis of a global collection of clinical isolates to show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones.Abstract:
Lung infections with Mycobacterium abscessus, a species of multidrug-resistant nontuberculous mycobacteria, are emerging as an important global threat to individuals with cystic fibrosis (CF), in whom M. abscessus accelerates inflammatory lung damage, leading to increased morbidity and mortality. Previously, M. abscessus was thought to be independently acquired by susceptible individuals from the environment. However, using whole-genome analysis of a global collection of clinical isolates, we show that the majority of M. abscessus infections are acquired through transmission, potentially via fomites and aerosols, of recently emerged dominant circulating clones that have spread globally. We demonstrate that these clones are associated with worse clinical outcomes, show increased virulence in cell-based and mouse infection models, and thus represent an urgent international infection challenge.read more
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British Thoracic Society guidelines for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
Charles S. Haworth,John Banks,Toby Capstick,Andrew J. Fisher,Thomas Gorsuch,Ian F. Laurenson,Andrew R. Leitch,Michael R. Loebinger,Heather Milburn,Mark Nightingale,Peter Ormerod,Delane Shingadia,David Smith,Nuala Whitehead,Robert Wilson,R. Andres Floto,R. Andres Floto +16 more
TL;DR: Recommendations and recommendations on what samples should be used to detect pulmonary non-tuberculous mycobacterial infection and how to define lung disease attributable to NTM infection are presented.
Journal ArticleDOI
The future of cystic fibrosis care: a global perspective
Scott C. Bell,Marcus A. Mall,Hector H. Gutierrez,Milan Macek,Susan Madge,Jane C. Davies,Pierre-Régis Burgel,Elizabeth Tullis,Claudio Castaños,Carlo Castellani,Catherine A. Byrnes,Fiona Cathcart,Sanjay H. Chotirmall,Rebecca Cosgriff,Irmgard Eichler,Isabelle Fajac,Christopher H. Goss,Pavel Drevinek,Philip M. Farrell,Anna M. Gravelle,Trudy Havermans,Nicole Mayer-Hamblett,Nataliya Kashirskaya,Eitan Kerem,Joseph L. Mathew,Edward F. McKone,Lutz Naehrlich,Samya Z. Nasr,Gabriela R. Oates,Ciaran O'Neill,Ulrike Pypops,Karen S. Raraigh,Steven M. Rowe,Kevin W Southern,Sheila Sivam,Anne L. Stephenson,Anne L. Stephenson,Marco Zampoli,Felix Ratjen +38 more
TL;DR: Advances in clinical care have been multifaceted and include earlier diagnosis through the implementation of newborn screening programmes, formalised airway clearance therapy, and reduced malnutrition through the use of effective pancreatic enzyme replacement and a high-energy, high-protein diet.
Journal ArticleDOI
Non-tuberculous mycobacteria and the rise of Mycobacterium abscessus.
TL;DR: The proposed infection process of M. abscessus, its virulence factors and host interactions, mechanisms of drug resistance and drug development are discussed and the commonalities and differences are highlighted with other NTM species.
Journal ArticleDOI
British Thoracic Society Guideline for the management of non-tuberculous mycobacterial pulmonary disease (NTM-PD)
Charles S. Haworth,John Banks,Toby Capstick,Andrew J. Fisher,Thomas Gorsuch,Ian F Laurenson,Andrew R. Leitch,Michael R. Loebinger,Heather Milburn,Mark Nightingale,Peter Ormerod,Delane Shingadia,David Smith,Nuala Whitehead,Robert Wilson,R. Andres Floto +15 more
TL;DR: The full guideline for the management of non-tuberculous mycobacterial pulmonary disease is published in Thorax and a summary of the recommendations and good practice points is provided.
Journal ArticleDOI
The Rise of Non-Tuberculosis Mycobacterial Lung Disease
Champa N. Ratnatunga,Viviana P. Lutzky,Andreas Kupz,Andreas Kupz,Denise L. Doolan,Denise L. Doolan,David W. Reid,Matthew A. Field,Matthew A. Field,Scott C. Bell,Rachel Thomson,John J. Miles,John J. Miles +12 more
TL;DR: The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally and due to climate change, the Tropics are expanding which will increase NTM infection regions.
References
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Heng Li,Bob Handsaker,Alec Wysoker,T. J. Fennell,Jue Ruan,Nils Homer,Gabor T. Marth,Gonçalo R. Abecasis,Richard Durbin +8 more
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An official ATS/IDSA statement: diagnosis, treatment, and prevention of nontuberculous mycobacterial diseases.
David E. Griffith,Timothy R. Aksamit,Barbara A. Brown-Elliott,Antonino Catanzaro,Charles L. Daley,Fred M. Gordin,Steven M. Holland,Robert Horsburgh,Gwen A. Huitt,Michael F. Iademarco,Michael D. Iseman,Kenneth N. Olivier,Stephen J. Ruoss,C. Fordham von Reyn,Richard J. Wallace,Kevin L. Winthrop +15 more
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